Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases
BackgroundStaphylococcus aureus is a well-known bacterium associated with carriage and responsible for different types of infections. The Panton-Valentine leucocidin (PVL) is a key virulence factor causing tissue necrosis. PVL can, however, be present in both benign and life-threatening infections.C...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1003708/full |
| _version_ | 1798021877156806656 |
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| author | Sophie Goemanne Anne Tilmanne Dominique Biarent Pierre Smeesters Pierre Smeesters Pierre Smeesters Paolo Simoni Bhavna Ansuya Mahadeb Alfredo Vicinanza |
| author_facet | Sophie Goemanne Anne Tilmanne Dominique Biarent Pierre Smeesters Pierre Smeesters Pierre Smeesters Paolo Simoni Bhavna Ansuya Mahadeb Alfredo Vicinanza |
| author_sort | Sophie Goemanne |
| collection | DOAJ |
| description | BackgroundStaphylococcus aureus is a well-known bacterium associated with carriage and responsible for different types of infections. The Panton-Valentine leucocidin (PVL) is a key virulence factor causing tissue necrosis. PVL can, however, be present in both benign and life-threatening infections.Case reports and managementWe present three pediatric severe infections occurring over a period of only three weeks, in February 2021, and caused by genetically unrelated methicillin-sensitive Staphylococcus aureus producing PVL in a tertiary children’s hospital in Belgium. The first one presented with necrotizing pneumonia, the second one with a neck abscess extended to the mediastinum, and the last one had sacral osteomyelitis complicated by endocarditis. The management of these infections is mostly based on expert opinions. The most appropriate treatment seems to be the combination of early surgical drainage of infected collections with an antibiotic regimen associating two antibiotics; beta-lactams and either clindamycin or linezolid. Human immunoglobulins also appear to be useful as adjunctive therapy.ConclusionPVL-producing Staphylococcus aureus is associated with life-threatening infections in children. Prompt management is needed including surgery and appropriate antibiotic regimens. |
| first_indexed | 2024-04-11T17:20:38Z |
| format | Article |
| id | doaj.art-c34f730034d443a68469bbe73ebe81e1 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T17:20:38Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-c34f730034d443a68469bbe73ebe81e12022-12-22T04:12:30ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-10-011010.3389/fped.2022.10037081003708Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin casesSophie Goemanne0Anne Tilmanne1Dominique Biarent2Pierre Smeesters3Pierre Smeesters4Pierre Smeesters5Paolo Simoni6Bhavna Ansuya Mahadeb7Alfredo Vicinanza8Department of Pediatrics, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumDivision of Pediatric Infectious Diseases and Infection Prevention and Control, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumPediatric Intensive Care Unit, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumDepartment of Pediatrics, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumDivision of Pediatric Infectious Diseases and Infection Prevention and Control, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumLaboratory of Molecular Bacteriology, Université Libre de Bruxelles (ULB), Brussels, BelgiumDepartment of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumDepartment of Microbiology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumPediatric Intensive Care Unit, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, BelgiumBackgroundStaphylococcus aureus is a well-known bacterium associated with carriage and responsible for different types of infections. The Panton-Valentine leucocidin (PVL) is a key virulence factor causing tissue necrosis. PVL can, however, be present in both benign and life-threatening infections.Case reports and managementWe present three pediatric severe infections occurring over a period of only three weeks, in February 2021, and caused by genetically unrelated methicillin-sensitive Staphylococcus aureus producing PVL in a tertiary children’s hospital in Belgium. The first one presented with necrotizing pneumonia, the second one with a neck abscess extended to the mediastinum, and the last one had sacral osteomyelitis complicated by endocarditis. The management of these infections is mostly based on expert opinions. The most appropriate treatment seems to be the combination of early surgical drainage of infected collections with an antibiotic regimen associating two antibiotics; beta-lactams and either clindamycin or linezolid. Human immunoglobulins also appear to be useful as adjunctive therapy.ConclusionPVL-producing Staphylococcus aureus is associated with life-threatening infections in children. Prompt management is needed including surgery and appropriate antibiotic regimens.https://www.frontiersin.org/articles/10.3389/fped.2022.1003708/fullStaphylococcus aureusPanton-Valentine leucocidinsevere infectionschildrenmethicillin-sensitive Staphylococcus aureus |
| spellingShingle | Sophie Goemanne Anne Tilmanne Dominique Biarent Pierre Smeesters Pierre Smeesters Pierre Smeesters Paolo Simoni Bhavna Ansuya Mahadeb Alfredo Vicinanza Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases Frontiers in Pediatrics Staphylococcus aureus Panton-Valentine leucocidin severe infections children methicillin-sensitive Staphylococcus aureus |
| title | Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases |
| title_full | Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases |
| title_fullStr | Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases |
| title_full_unstemmed | Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases |
| title_short | Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases |
| title_sort | severe staphylococcus aureus infections in children case reports and management of positive panton valentine leucocidin cases |
| topic | Staphylococcus aureus Panton-Valentine leucocidin severe infections children methicillin-sensitive Staphylococcus aureus |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1003708/full |
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