Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands
<p>Abstract</p> <p>Background</p> <p>To guide policy and control measures, decent scientific data are needed for a comprehensive assessment of epidemiological, clinical and virological characteristics of the First Few hundred (FF100) cases. We discuss the feasibility of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Online Access: | http://www.aricjournal.com/content/1/1/30 |
| _version_ | 1811281243003682816 |
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| author | van Gageldonk-Lafeber Arianne B van der Sande Marianne AB Meijer Adam Friesema Ingrid HM Donker Gé A Reimerink Johan Robert-Du Ry van Beest Holle Mirna Prins Jan M Isken Leslie Schellevis François G van der Lubben Mariken IM |
| author_facet | van Gageldonk-Lafeber Arianne B van der Sande Marianne AB Meijer Adam Friesema Ingrid HM Donker Gé A Reimerink Johan Robert-Du Ry van Beest Holle Mirna Prins Jan M Isken Leslie Schellevis François G van der Lubben Mariken IM |
| author_sort | van Gageldonk-Lafeber Arianne B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To guide policy and control measures, decent scientific data are needed for a comprehensive assessment of epidemiological, clinical and virological characteristics of the First Few hundred (FF100) cases. We discuss the feasibility of the FF100 approach during the 2009 pandemic and the added value compared with alternative data sources available.</p> <p>Methods</p> <p>The pandemic preparedness plan enabled us to perform a case–control study, assessing patient characteristics and risk factors for experiencing symptomatic influenza A(H1N1)2009 infection and providing insight into transmission. We assessed to what extent timely and novel data were generated compared to other available data sources.</p> <p>Results</p> <p>In May-December 2009, a total of 68 cases and 48 controls were included in the study. Underlying non-respiratory diseases were significantly more common among cases compared to controls, while a protective effect was found for frequent hand washing. Seroconversion was found for 7/30 controls (23%), and persisting high titers for 4/30 controls (13%). The labour-intensive study design resulted in slow and restricted recruitment.</p> <p>Conclusions</p> <p>The findings of our case–control study gave new insights in transmission risks and possible interventions for improved control. Nevertheless, the FF100 approach lacked timeliness and power due to limited recruitment. For future pandemics we suggest pooling data from several countries, to enable collecting sufficient data in a relatively short period.</p> |
| first_indexed | 2024-04-13T01:28:53Z |
| format | Article |
| id | doaj.art-c3523288b1e04dd7930402429e748625 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-13T01:28:53Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-c3523288b1e04dd7930402429e7486252022-12-22T03:08:33ZengBMCAntimicrobial Resistance and Infection Control2047-29942012-09-01113010.1186/2047-2994-1-30Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlandsvan Gageldonk-Lafeber Arianne Bvan der Sande Marianne ABMeijer AdamFriesema Ingrid HMDonker Gé AReimerink JohanRobert-Du Ry van Beest Holle MirnaPrins Jan MIsken LeslieSchellevis François Gvan der Lubben Mariken IM<p>Abstract</p> <p>Background</p> <p>To guide policy and control measures, decent scientific data are needed for a comprehensive assessment of epidemiological, clinical and virological characteristics of the First Few hundred (FF100) cases. We discuss the feasibility of the FF100 approach during the 2009 pandemic and the added value compared with alternative data sources available.</p> <p>Methods</p> <p>The pandemic preparedness plan enabled us to perform a case–control study, assessing patient characteristics and risk factors for experiencing symptomatic influenza A(H1N1)2009 infection and providing insight into transmission. We assessed to what extent timely and novel data were generated compared to other available data sources.</p> <p>Results</p> <p>In May-December 2009, a total of 68 cases and 48 controls were included in the study. Underlying non-respiratory diseases were significantly more common among cases compared to controls, while a protective effect was found for frequent hand washing. Seroconversion was found for 7/30 controls (23%), and persisting high titers for 4/30 controls (13%). The labour-intensive study design resulted in slow and restricted recruitment.</p> <p>Conclusions</p> <p>The findings of our case–control study gave new insights in transmission risks and possible interventions for improved control. Nevertheless, the FF100 approach lacked timeliness and power due to limited recruitment. For future pandemics we suggest pooling data from several countries, to enable collecting sufficient data in a relatively short period.</p>http://www.aricjournal.com/content/1/1/30 |
| spellingShingle | van Gageldonk-Lafeber Arianne B van der Sande Marianne AB Meijer Adam Friesema Ingrid HM Donker Gé A Reimerink Johan Robert-Du Ry van Beest Holle Mirna Prins Jan M Isken Leslie Schellevis François G van der Lubben Mariken IM Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands Antimicrobial Resistance and Infection Control |
| title | Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands |
| title_full | Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands |
| title_fullStr | Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands |
| title_full_unstemmed | Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands |
| title_short | Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands |
| title_sort | utility of the first few100 approach during the 2009 influenza a h1n1 pandemic in the netherlands |
| url | http://www.aricjournal.com/content/1/1/30 |
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