Autoregulation of the LIM kinases by their PDZ domain

Abstract LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament severing, and are key nodes between Rho GTPase cascades and actin. The two mammalian LIMKs, LIMK1 and LIMK2,...

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Autors principals: Gabriela Casanova-Sepúlveda, Joel A. Sexton, Benjamin E. Turk, Titus J. Boggon
Format: Article
Idioma:English
Publicat: Nature Portfolio 2023-12-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-023-44148-4