Autoregulation of the LIM kinases by their PDZ domain

Abstract LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament severing, and are key nodes between Rho GTPase cascades and actin. The two mammalian LIMKs, LIMK1 and LIMK2,...

詳細記述

書誌詳細
主要な著者: Gabriela Casanova-Sepúlveda, Joel A. Sexton, Benjamin E. Turk, Titus J. Boggon
フォーマット: 論文
言語:English
出版事項: Nature Portfolio 2023-12-01
シリーズ:Nature Communications
オンライン・アクセス:https://doi.org/10.1038/s41467-023-44148-4