Autoregulation of the LIM kinases by their PDZ domain
Abstract LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament severing, and are key nodes between Rho GTPase cascades and actin. The two mammalian LIMKs, LIMK1 and LIMK2,...
主要な著者: | , , , |
---|---|
フォーマット: | 論文 |
言語: | English |
出版事項: |
Nature Portfolio
2023-12-01
|
シリーズ: | Nature Communications |
オンライン・アクセス: | https://doi.org/10.1038/s41467-023-44148-4 |