METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES
Objective. Background 99mTc-technephyt hepatobiliary scintigraphy (HBS) and 13C-methacetin breath test were used as a quantitative methods to evaluate liver function. The aim of this study was to compare future remnant liver function assessed by 99mTc-technephyt dynamic hepatobiliary scintigraphy wi...
| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Russian |
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QUASAR, LLC
2015-04-01
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| coleção: | Исследования и практика в медицине |
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| Acesso em linha: | https://www.rpmj.ru/rpmj/article/view/33 |
| _version_ | 1826559300598759424 |
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| author | D. V. Sidorov N. A. Rubtsova A. V. Leontyev M. V. Lozhkin L. O. Petrov T. N. Lazutina I. V. Pylova P. A. Korolev A. G. Isaeva |
| author_facet | D. V. Sidorov N. A. Rubtsova A. V. Leontyev M. V. Lozhkin L. O. Petrov T. N. Lazutina I. V. Pylova P. A. Korolev A. G. Isaeva |
| author_sort | D. V. Sidorov |
| collection | DOAJ |
| description | Objective. Background 99mTc-technephyt hepatobiliary scintigraphy (HBS) and 13C-methacetin breath test were used as a quantitative methods to evaluate liver function. The aim of this study was to compare future remnant liver function assessed by 99mTc-technephyt dynamic hepatobiliary scintigraphy with results of methacetin breath test in the prediction of liver failure after major liver resection. Materials and methods. Methacetin breath test and 99mTc-technephyt hepatobiliary scintigraphy were performed prior to major resection in 53 high-risk patients, including 48 patients with hepatic metastases from colorectal cancer and 5 patients with hepatocellular carcinoma . Liver function determined with HBS was compared with methacetin breath test by unified scale.Results. A strong positive association (r = 0.706) was found between 13C-methacetin breath test determined with 99mTc-technephyt hepatobiliary scintigraphyConclusions. Preoperative 99mTc-technephyt hepatobiliary scintigraphy with 13C-methacetin breath test are a valuable techniques to estimate the risk of postoperative liver failure.They offers a unique combination of functional liver uptake and excretion with the ability to assess the preoperative liver function reserve and to estimate the remnant liver function preoperatively . This combination might significantly improve preoperative evaluation and postoperative outcomes in liver surgery. |
| first_indexed | 2024-04-10T01:27:35Z |
| format | Article |
| id | doaj.art-c353343ef022497cbbe86e66a1281af6 |
| institution | Directory Open Access Journal |
| issn | 2410-1893 |
| language | Russian |
| last_indexed | 2025-03-14T08:58:12Z |
| publishDate | 2015-04-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj.art-c353343ef022497cbbe86e66a1281af62025-03-02T12:44:05ZrusQUASAR, LLCИсследования и практика в медицине2410-18932015-04-0121132010.17709/2409-2231-2015-2-1-13-2016METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVESD. V. Sidorov0N. A. Rubtsova1A. V. Leontyev2M. V. Lozhkin3L. O. Petrov4T. N. Lazutina5I. V. Pylova6P. A. Korolev7A. G. Isaeva8P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284P. Hertsen MORI (Moscow, Russian Federation) 3, 2 Botkinskiy proezd, Moscow , Russian Federation,125284SBEY HPO M.I. Sechenov First MSMU 8-2, Trubetskaya, Moscow, Russian Federation, 119991Objective. Background 99mTc-technephyt hepatobiliary scintigraphy (HBS) and 13C-methacetin breath test were used as a quantitative methods to evaluate liver function. The aim of this study was to compare future remnant liver function assessed by 99mTc-technephyt dynamic hepatobiliary scintigraphy with results of methacetin breath test in the prediction of liver failure after major liver resection. Materials and methods. Methacetin breath test and 99mTc-technephyt hepatobiliary scintigraphy were performed prior to major resection in 53 high-risk patients, including 48 patients with hepatic metastases from colorectal cancer and 5 patients with hepatocellular carcinoma . Liver function determined with HBS was compared with methacetin breath test by unified scale.Results. A strong positive association (r = 0.706) was found between 13C-methacetin breath test determined with 99mTc-technephyt hepatobiliary scintigraphyConclusions. Preoperative 99mTc-technephyt hepatobiliary scintigraphy with 13C-methacetin breath test are a valuable techniques to estimate the risk of postoperative liver failure.They offers a unique combination of functional liver uptake and excretion with the ability to assess the preoperative liver function reserve and to estimate the remnant liver function preoperatively . This combination might significantly improve preoperative evaluation and postoperative outcomes in liver surgery.https://www.rpmj.ru/rpmj/article/view/33liver resection, liver failure, liver function tests |
| spellingShingle | D. V. Sidorov N. A. Rubtsova A. V. Leontyev M. V. Lozhkin L. O. Petrov T. N. Lazutina I. V. Pylova P. A. Korolev A. G. Isaeva METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES Исследования и практика в медицине liver resection, liver failure, liver function tests |
| title | METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES |
| title_full | METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES |
| title_fullStr | METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES |
| title_full_unstemmed | METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES |
| title_short | METHODS OF EVALUATION OF THE FUNCTIONAL STATUS OF THE LIVER IN THE PLANNING OF ANATOMICAL RESECTIONS ABOUT PRIMARY AND METASTATIC TUMORS: CURRENT STATE OF THE PROBLEM, THEIR OWN EXPERIENCE AND PERSPECTIVES |
| title_sort | methods of evaluation of the functional status of the liver in the planning of anatomical resections about primary and metastatic tumors current state of the problem their own experience and perspectives |
| topic | liver resection, liver failure, liver function tests |
| url | https://www.rpmj.ru/rpmj/article/view/33 |
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