Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey
Background: The prevalence of chronic kidney disease (CKD) correlates with the prevalence of hypertension (HT). We studied the prevalence and predictors of CKD in a representative sample of the Romanian adult population. Methods: A sample of 1470 subjects were enrolled in the SEPHAR IV (Study for th...
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/3199 |
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| author | Călin Pop Oana Florentina Gheorghe Fronea Ioana Antonia Branea Lucian Mihai Itu Roxana Darabont Irinel Parepa Theodora Benedek Maria Dorobantu |
| author_facet | Călin Pop Oana Florentina Gheorghe Fronea Ioana Antonia Branea Lucian Mihai Itu Roxana Darabont Irinel Parepa Theodora Benedek Maria Dorobantu |
| author_sort | Călin Pop |
| collection | DOAJ |
| description | Background: The prevalence of chronic kidney disease (CKD) correlates with the prevalence of hypertension (HT). We studied the prevalence and predictors of CKD in a representative sample of the Romanian adult population. Methods: A sample of 1470 subjects were enrolled in the SEPHAR IV (Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk) survey. All subjects were evaluated for blood pressure (BP) and extensive evaluations of target organ damage, blood, and urine samples were undertaken. Results: A total of 883 subjects were included in the statistical analysis. Those experiencing CKD with an eGFR < 60 mL/min/1.73 m<sup>2</sup> were older at 71.94 ± 7.4 years (n = 19, 2.15%) compared with those without renal impairment at 50.3 ± 16.21 years (n = 864, 97.85%), <i>p</i> < 0.0001. The prevalence of CKD among hypertensives (379 from 883) was 4.49% (17/379), while 17 out of 19 subjects with CKD had HT (89.47%). After adjusting for age, sex, and diabetic status, only serum uric acid (SUR) > 6.9 mg/dL (OR: 6.61; 95% CI: 2.063, 10.83; <i>p</i> = 0.004) was an independent risk factor and a predictor of CKD. Conclusions: The prevalence of CKD in hypertensive Romanian adults was more than ten times higher than in the normotensive population. Levels of SUR > 6.9 mg/dL were predictors of CKD. |
| first_indexed | 2024-03-09T17:08:41Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:41Z |
| publishDate | 2022-12-01 |
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| series | Diagnostics |
| spelling | doaj.art-c355a489683c4f45b8e6465566905bb72023-11-24T14:20:27ZengMDPI AGDiagnostics2075-44182022-12-011212319910.3390/diagnostics12123199Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV SurveyCălin Pop0Oana Florentina Gheorghe Fronea1Ioana Antonia Branea2Lucian Mihai Itu3Roxana Darabont4Irinel Parepa5Theodora Benedek6Maria Dorobantu7Emergency Clinical County Hospital of Baia Mare, 430130 Baia Mare, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bulevardul Eroii Sanitari nr. 8, Sector 5, 050474 Bucuresti, RomaniaDepartment of Mathematics and Computer Science, Transilvania University of Brasov, B-dul Eroilor nr. 29, 500036 Brașov, RomaniaDepartment of Automation and Information Technology, Transilvania University of Brasov, B-dul Eroilor nr. 29, 500036 Brașov, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bulevardul Eroii Sanitari nr. 8, Sector 5, 050474 Bucuresti, Romania“Ovidius” State University Constanta, Faculty of Medicine, Cardiology Dept, Campus Aleea Universitatii nr. 1, 900470 Constanta, RomaniaCardiology Department, County Clinical Emergency Hospital, University of Medicine and Pharmacy, Street Gh. Marinescu, 38, 540142 Targu Mures, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bulevardul Eroii Sanitari nr. 8, Sector 5, 050474 Bucuresti, RomaniaBackground: The prevalence of chronic kidney disease (CKD) correlates with the prevalence of hypertension (HT). We studied the prevalence and predictors of CKD in a representative sample of the Romanian adult population. Methods: A sample of 1470 subjects were enrolled in the SEPHAR IV (Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk) survey. All subjects were evaluated for blood pressure (BP) and extensive evaluations of target organ damage, blood, and urine samples were undertaken. Results: A total of 883 subjects were included in the statistical analysis. Those experiencing CKD with an eGFR < 60 mL/min/1.73 m<sup>2</sup> were older at 71.94 ± 7.4 years (n = 19, 2.15%) compared with those without renal impairment at 50.3 ± 16.21 years (n = 864, 97.85%), <i>p</i> < 0.0001. The prevalence of CKD among hypertensives (379 from 883) was 4.49% (17/379), while 17 out of 19 subjects with CKD had HT (89.47%). After adjusting for age, sex, and diabetic status, only serum uric acid (SUR) > 6.9 mg/dL (OR: 6.61; 95% CI: 2.063, 10.83; <i>p</i> = 0.004) was an independent risk factor and a predictor of CKD. Conclusions: The prevalence of CKD in hypertensive Romanian adults was more than ten times higher than in the normotensive population. Levels of SUR > 6.9 mg/dL were predictors of CKD.https://www.mdpi.com/2075-4418/12/12/3199prevalencechronic kidney diseasehypertensionuric acid levels |
| spellingShingle | Călin Pop Oana Florentina Gheorghe Fronea Ioana Antonia Branea Lucian Mihai Itu Roxana Darabont Irinel Parepa Theodora Benedek Maria Dorobantu Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey Diagnostics prevalence chronic kidney disease hypertension uric acid levels |
| title | Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey |
| title_full | Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey |
| title_fullStr | Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey |
| title_full_unstemmed | Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey |
| title_short | Prevalence and Predictors of Renal Disease in a National Representative Sample of the Romanian Adult Population: Data from the SEPHAR IV Survey |
| title_sort | prevalence and predictors of renal disease in a national representative sample of the romanian adult population data from the sephar iv survey |
| topic | prevalence chronic kidney disease hypertension uric acid levels |
| url | https://www.mdpi.com/2075-4418/12/12/3199 |
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