Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

Peptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others. This threshold hierarchy could reside at the receptor level, where different response pathways branch off at differe...

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Bibliographic Details
Main Authors: Hugo Antonius van den Berg, Kristin eLadell, Kelly eMiners, Bruno eLaugel, Sian eLlewellyn-Lacey, Mathew eClement, David K Cole, Emma eGostick, Linda eWooldridge, Andrew Kelvin Sewell, John Stephen Bridgeman, David A Price
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
Kinetics
T-cell receptor
peptide ligands
T-cell cross-reactivity
T-cell activation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00250/full

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