Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries
Lead is known to be highly toxic to humans, causing various disorders infetal development. An experiment was conducted to examine the effects of lead acetate on the structural organization of female rat ovaries. The study involved 40 non-linear female rats divided into four groups: a control group,...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/9/769 |
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| author | Adam Osowski Larysa Fedoniuk Yaroslav Bilyk Olena Fedchyshyn Mykhailo Sas Solomiia Kramar Yuliia Lomakina Volodymyr Fik Sofija Chorniy Joanna Wojtkiewicz |
| author_facet | Adam Osowski Larysa Fedoniuk Yaroslav Bilyk Olena Fedchyshyn Mykhailo Sas Solomiia Kramar Yuliia Lomakina Volodymyr Fik Sofija Chorniy Joanna Wojtkiewicz |
| author_sort | Adam Osowski |
| collection | DOAJ |
| description | Lead is known to be highly toxic to humans, causing various disorders infetal development. An experiment was conducted to examine the effects of lead acetate on the structural organization of female rat ovaries. The study involved 40 non-linear female rats divided into four groups: a control group, a low-dose group, a moderate-dose group, and a high-dose group. The rats were given lead acetate solutions in varying doses for 30 days, and their ovarian tissue was examined using light microscopy.The results showed that increasing doses of lead acetate led to morphological changes in the cortex and medulla of the rat ovaries. The changes were characterized by a decrease in ovarian mass, alterations in the thickness of the tunica albuginea (protein envelope), and a reduction in the number of follicles. Light microscopy revealed that exposure to lead acetate resulted in a significant decrease in the number of follicles in all experimental groups, with the high-dose group experiencing the most significant decrease.These findings suggest that lead acetate has a dose-dependent negative impact on the morphology and function of female rat ovaries. Further studies are needed to investigate the potential impact of lead on human ovarian tissue. |
| first_indexed | 2024-03-10T21:53:58Z |
| format | Article |
| id | doaj.art-c3578e9704ac4946a7ab8d14a701987c |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T21:53:58Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-c3578e9704ac4946a7ab8d14a701987c2023-11-19T13:14:54ZengMDPI AGToxics2305-63042023-09-0111976910.3390/toxics11090769Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat OvariesAdam Osowski0Larysa Fedoniuk1Yaroslav Bilyk2Olena Fedchyshyn3Mykhailo Sas4Solomiia Kramar5Yuliia Lomakina6Volodymyr Fik7Sofija Chorniy8Joanna Wojtkiewicz9Department of Pathophysiology, University of Warmia and Mazury in Olsztyn, 2 Oczapowskiego Street, 10-719 Olsztyn, PolandHistology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, UkraineHistology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, UkraineHistology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, UkraineHistology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, UkraineHistology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, UkraineDepartment of Medical Biology and Genetics, Bukovinian State Medical University, 15 Yu. Fedkvich Street, 58000 Chernivtsi, UkraineDepartment of Normal Anatomy, Danylo Halytsky Lviv National Medical University, 69 Pekarska Street, 79010 Lviv, UkraineHistology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, UkraineDepartment of Pathophysiology, University of Warmia and Mazury in Olsztyn, 2 Oczapowskiego Street, 10-719 Olsztyn, PolandLead is known to be highly toxic to humans, causing various disorders infetal development. An experiment was conducted to examine the effects of lead acetate on the structural organization of female rat ovaries. The study involved 40 non-linear female rats divided into four groups: a control group, a low-dose group, a moderate-dose group, and a high-dose group. The rats were given lead acetate solutions in varying doses for 30 days, and their ovarian tissue was examined using light microscopy.The results showed that increasing doses of lead acetate led to morphological changes in the cortex and medulla of the rat ovaries. The changes were characterized by a decrease in ovarian mass, alterations in the thickness of the tunica albuginea (protein envelope), and a reduction in the number of follicles. Light microscopy revealed that exposure to lead acetate resulted in a significant decrease in the number of follicles in all experimental groups, with the high-dose group experiencing the most significant decrease.These findings suggest that lead acetate has a dose-dependent negative impact on the morphology and function of female rat ovaries. Further studies are needed to investigate the potential impact of lead on human ovarian tissue.https://www.mdpi.com/2305-6304/11/9/769rat ovarieslead toxicitymorphology of ovarieslight microscopy |
| spellingShingle | Adam Osowski Larysa Fedoniuk Yaroslav Bilyk Olena Fedchyshyn Mykhailo Sas Solomiia Kramar Yuliia Lomakina Volodymyr Fik Sofija Chorniy Joanna Wojtkiewicz Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries Toxics rat ovaries lead toxicity morphology of ovaries light microscopy |
| title | Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries |
| title_full | Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries |
| title_fullStr | Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries |
| title_full_unstemmed | Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries |
| title_short | Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries |
| title_sort | lead exposure assessment and its impact on the structural organization and morphological peculiarities of rat ovaries |
| topic | rat ovaries lead toxicity morphology of ovaries light microscopy |
| url | https://www.mdpi.com/2305-6304/11/9/769 |
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