CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection.

CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection.

Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity. However, although CD4+CD25+FoxP3+ regulatory T cells (T(regs)) are known to suppress Th1...

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Bibliographic Details
Main Authors:	Joseph D Turner, Gavin R Jenkins, Karen G Hogg, Sarah A Aynsley, Ross A Paveley, Peter C Cook, Mark C Coles, Adrian P Mountford
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-08-01
Series:	PLoS Neglected Tropical Diseases
Online Access:	http://europepmc.org/articles/PMC3153428?pdf=render

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