Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship

Interferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to ep...

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Main Authors: Giulia Finotti, Nicola Tamassia, Marco A. Cassatella
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01015/full
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author Giulia Finotti
Nicola Tamassia
Marco A. Cassatella
author_facet Giulia Finotti
Nicola Tamassia
Marco A. Cassatella
author_sort Giulia Finotti
collection DOAJ
description Interferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to epithelial cells and discrete leukocyte subsets, including the plasmacytoid dendritic cells (pDCs). In the latter case, current data, discussed in this minireview, indicate that IFNλs positively regulate various pDC functions, including pDC expression of interferon-dependent gene (ISG) mRNAs, production of cytokines, survival, and phenotype. Although the knowledge of the effects on pDCs by IFNλs is still incomplete, we speculate that the peculiar pDC responsiveness to IFNλs provide unique advantages for these innate immune cells, not only for viral infections but also during autoimmune disorders and/or tumors, in which pDC involvement and activation variably contribute to their pathogenesis.
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spelling doaj.art-c358ad3373af41d98906534d5b72ce3d2022-12-22T03:15:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-08-01810.3389/fimmu.2017.01015291888Interferon-λs and Plasmacytoid Dendritic Cells: A Close RelationshipGiulia Finotti0Nicola Tamassia1Marco A. Cassatella2Department of Medicine, Section of General Pathology, University of Verona, Verona, ItalyDepartment of Medicine, Section of General Pathology, University of Verona, Verona, ItalyDepartment of Medicine, Section of General Pathology, University of Verona, Verona, ItalyInterferon lambdas (IFNλs) are recently discovered cytokines acting not only at the first line of defense against viral infections but also at the mucosal barriers. In fact, a peculiar feature of the IFNλ system is the restricted expression of the functional IFNλR, which is known to be limited to epithelial cells and discrete leukocyte subsets, including the plasmacytoid dendritic cells (pDCs). In the latter case, current data, discussed in this minireview, indicate that IFNλs positively regulate various pDC functions, including pDC expression of interferon-dependent gene (ISG) mRNAs, production of cytokines, survival, and phenotype. Although the knowledge of the effects on pDCs by IFNλs is still incomplete, we speculate that the peculiar pDC responsiveness to IFNλs provide unique advantages for these innate immune cells, not only for viral infections but also during autoimmune disorders and/or tumors, in which pDC involvement and activation variably contribute to their pathogenesis.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01015/fullplasmacytoid dendritic cellsinterferon lambdainnate immunityIFNαIL-3CXCL10
spellingShingle Giulia Finotti
Nicola Tamassia
Marco A. Cassatella
Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
Frontiers in Immunology
plasmacytoid dendritic cells
interferon lambda
innate immunity
IFNα
IL-3
CXCL10
title Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
title_full Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
title_fullStr Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
title_full_unstemmed Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
title_short Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship
title_sort interferon λs and plasmacytoid dendritic cells a close relationship
topic plasmacytoid dendritic cells
interferon lambda
innate immunity
IFNα
IL-3
CXCL10
url http://journal.frontiersin.org/article/10.3389/fimmu.2017.01015/full
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AT marcoacassatella interferonlsandplasmacytoiddendriticcellsacloserelationship