Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center
Abstract Objective Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare malignancy with various treatment strategies and outcomes. The purpose of this study was to evaluate the clinical characteristics and survival outcomes and identify prognostic factors in patients with SCC...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.1216 |
| _version_ | 1827344553321955328 |
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| author | Yi‐Ting Huang Jiunn‐Liang Wu Wen‐Yuan Chao Wei‐Ting Lee |
| author_facet | Yi‐Ting Huang Jiunn‐Liang Wu Wen‐Yuan Chao Wei‐Ting Lee |
| author_sort | Yi‐Ting Huang |
| collection | DOAJ |
| description | Abstract Objective Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare malignancy with various treatment strategies and outcomes. The purpose of this study was to evaluate the clinical characteristics and survival outcomes and identify prognostic factors in patients with SCC of EAC. Methods Twenty‐one patients with SCC of EAC treated in a single tertiary center between 2009 and 2021 were retrospectively reviewed and analyzed. The modified Pittsburgh classification system was applied for staging. Factors associated with survival were identified by univariate survival analysis. Results The mean age at diagnosis was 61 years (range: 41–79 years). Early‐stage (T1 + T2) accounts for 38.1% of the series and advanced‐stage (T3 + T4) accounts for 61.9%. Eighteen (85.7%) patients underwent primary surgery with curative intent. The 5‐year overall survival rate of the 21 patients was 67.4%. Tumor invasion to the otic capsule, eustachian tube, sigmoid sinus, and dura were associated with poor prognosis in univariate analysis (p = .046; .008; .027; and .08, respectively). Conclusions Factors predictive of less favorable survival include the history of COM, tumor invasion to the otic capsule, eustachian tube, sigmoid sinus, and dura. It is important to make a precise and systemic preoperative evaluation of disease extent. Level of Evidence 4 |
| first_indexed | 2024-03-07T22:48:50Z |
| format | Article |
| id | doaj.art-c358f2dccb884567b3d49e67b4fe6417 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-03-07T22:48:50Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-c358f2dccb884567b3d49e67b4fe64172024-02-23T12:00:37ZengWileyLaryngoscope Investigative Otolaryngology2378-80382024-02-0191n/an/a10.1002/lio2.1216Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary centerYi‐Ting Huang0Jiunn‐Liang Wu1Wen‐Yuan Chao2Wei‐Ting Lee3Department of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan City TaiwanDepartment of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan City TaiwanDepartment of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan City TaiwanDepartment of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan City TaiwanAbstract Objective Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare malignancy with various treatment strategies and outcomes. The purpose of this study was to evaluate the clinical characteristics and survival outcomes and identify prognostic factors in patients with SCC of EAC. Methods Twenty‐one patients with SCC of EAC treated in a single tertiary center between 2009 and 2021 were retrospectively reviewed and analyzed. The modified Pittsburgh classification system was applied for staging. Factors associated with survival were identified by univariate survival analysis. Results The mean age at diagnosis was 61 years (range: 41–79 years). Early‐stage (T1 + T2) accounts for 38.1% of the series and advanced‐stage (T3 + T4) accounts for 61.9%. Eighteen (85.7%) patients underwent primary surgery with curative intent. The 5‐year overall survival rate of the 21 patients was 67.4%. Tumor invasion to the otic capsule, eustachian tube, sigmoid sinus, and dura were associated with poor prognosis in univariate analysis (p = .046; .008; .027; and .08, respectively). Conclusions Factors predictive of less favorable survival include the history of COM, tumor invasion to the otic capsule, eustachian tube, sigmoid sinus, and dura. It is important to make a precise and systemic preoperative evaluation of disease extent. Level of Evidence 4https://doi.org/10.1002/lio2.1216external auditory canalprognostic factorsquamous cell carcinomasurvival outcometemporal bone |
| spellingShingle | Yi‐Ting Huang Jiunn‐Liang Wu Wen‐Yuan Chao Wei‐Ting Lee Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center Laryngoscope Investigative Otolaryngology external auditory canal prognostic factor squamous cell carcinoma survival outcome temporal bone |
| title | Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center |
| title_full | Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center |
| title_fullStr | Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center |
| title_full_unstemmed | Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center |
| title_short | Treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma: A retrospective study in a tertiary center |
| title_sort | treatment outcome and prognostic factors of external auditory canal squamous cell carcinoma a retrospective study in a tertiary center |
| topic | external auditory canal prognostic factor squamous cell carcinoma survival outcome temporal bone |
| url | https://doi.org/10.1002/lio2.1216 |
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