Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies
Little is known regarding associations between inflammatory biomarkers and objectively measured physical activity and sleep during and after chemotherapy for gynecologic cancer; thus, we conducted a longitudinal study to address this gap. Women with gynecologic cancer (patients) and non-cancer contr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3882 |
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| author | Danielle B. Tometich Aasha I. Hoogland Brent J. Small Michelle C. Janelsins Crystal Bryant Yvelise Rodriguez Brian D. Gonzalez Xiaoyin Li Hailey W. Bulls Brian W. James Bianca Arboleda Claudia Colon-Echevarria Mary K. Townsend Shelley S. Tworoger Paulo Rodriguez Laura B. Oswald Julienne E. Bower Sachin M. Apte Robert M. Wenham Hye Sook Chon Mian M. Shahzad Heather S. L. Jim |
| author_facet | Danielle B. Tometich Aasha I. Hoogland Brent J. Small Michelle C. Janelsins Crystal Bryant Yvelise Rodriguez Brian D. Gonzalez Xiaoyin Li Hailey W. Bulls Brian W. James Bianca Arboleda Claudia Colon-Echevarria Mary K. Townsend Shelley S. Tworoger Paulo Rodriguez Laura B. Oswald Julienne E. Bower Sachin M. Apte Robert M. Wenham Hye Sook Chon Mian M. Shahzad Heather S. L. Jim |
| author_sort | Danielle B. Tometich |
| collection | DOAJ |
| description | Little is known regarding associations between inflammatory biomarkers and objectively measured physical activity and sleep during and after chemotherapy for gynecologic cancer; thus, we conducted a longitudinal study to address this gap. Women with gynecologic cancer (patients) and non-cancer controls (controls) completed assessments before chemotherapy cycles 1, 3, and 6 (controls assessed contemporaneously), as well as at 6- and 12-month follow-ups. Physical activity and sleep were measured using wrist-worn actigraphs and sleep diaries, and blood was drawn to quantify circulating levels of inflammatory markers. Linear and quadratic random-effects mixed models and random-effects fluctuation mixed models were used to examine physical activity and sleep over time, as well as the associations with inflammatory biomarkers. On average, patients (<i>n</i> = 97) and controls (<i>n</i> = 104) were 62 and 58 years old, respectively. Compared to controls, patients were less active, more sedentary, had more time awake after sleep onset, and had lower sleep efficiency (<i>p</i>-values < 0.05). Across groups, higher levels of TNF-α were associated with more sedentary time and less efficient sleep (<i>p</i>-values ≤ 0.05). Higher levels of IL-1β, TNF-α, and IL-6 were associated with lower levels of light physical activity (<i>p</i>-values < 0.05). Associations between inflammatory biomarkers, physical activity, and sleep did not differ between patients and controls. Given these results, we speculate that inflammation may contribute to less physical activity and more sleep problems that persist even 12 months after completing chemotherapy. |
| first_indexed | 2024-03-11T00:30:44Z |
| format | Article |
| id | doaj.art-c359b1ac05e446ea9ed011ad179d243c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:44Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c359b1ac05e446ea9ed011ad179d243c2023-11-18T22:42:41ZengMDPI AGCancers2072-66942023-07-011515388210.3390/cancers15153882Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic MalignanciesDanielle B. Tometich0Aasha I. Hoogland1Brent J. Small2Michelle C. Janelsins3Crystal Bryant4Yvelise Rodriguez5Brian D. Gonzalez6Xiaoyin Li7Hailey W. Bulls8Brian W. James9Bianca Arboleda10Claudia Colon-Echevarria11Mary K. Townsend12Shelley S. Tworoger13Paulo Rodriguez14Laura B. Oswald15Julienne E. Bower16Sachin M. Apte17Robert M. Wenham18Hye Sook Chon19Mian M. Shahzad20Heather S. L. Jim21Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USASchool of Aging Studies, University of South Florida, Tampa, FL 33620, USADepartment of Surgery and Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USASection of Palliative Care and Medical Ethics, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USAMorsani College of Medicine, University of South Florida, Tampa, FL 33620, USAMorsani College of Medicine, University of South Florida, Tampa, FL 33620, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Immunology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USAHuntsman Cancer Institute, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84112, USADepartment of Gynecologic Oncology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Gynecologic Oncology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Gynecologic Oncology, Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USALittle is known regarding associations between inflammatory biomarkers and objectively measured physical activity and sleep during and after chemotherapy for gynecologic cancer; thus, we conducted a longitudinal study to address this gap. Women with gynecologic cancer (patients) and non-cancer controls (controls) completed assessments before chemotherapy cycles 1, 3, and 6 (controls assessed contemporaneously), as well as at 6- and 12-month follow-ups. Physical activity and sleep were measured using wrist-worn actigraphs and sleep diaries, and blood was drawn to quantify circulating levels of inflammatory markers. Linear and quadratic random-effects mixed models and random-effects fluctuation mixed models were used to examine physical activity and sleep over time, as well as the associations with inflammatory biomarkers. On average, patients (<i>n</i> = 97) and controls (<i>n</i> = 104) were 62 and 58 years old, respectively. Compared to controls, patients were less active, more sedentary, had more time awake after sleep onset, and had lower sleep efficiency (<i>p</i>-values < 0.05). Across groups, higher levels of TNF-α were associated with more sedentary time and less efficient sleep (<i>p</i>-values ≤ 0.05). Higher levels of IL-1β, TNF-α, and IL-6 were associated with lower levels of light physical activity (<i>p</i>-values < 0.05). Associations between inflammatory biomarkers, physical activity, and sleep did not differ between patients and controls. Given these results, we speculate that inflammation may contribute to less physical activity and more sleep problems that persist even 12 months after completing chemotherapy.https://www.mdpi.com/2072-6694/15/15/3882gynecologic cancerphysical activitysleepinflammation |
| spellingShingle | Danielle B. Tometich Aasha I. Hoogland Brent J. Small Michelle C. Janelsins Crystal Bryant Yvelise Rodriguez Brian D. Gonzalez Xiaoyin Li Hailey W. Bulls Brian W. James Bianca Arboleda Claudia Colon-Echevarria Mary K. Townsend Shelley S. Tworoger Paulo Rodriguez Laura B. Oswald Julienne E. Bower Sachin M. Apte Robert M. Wenham Hye Sook Chon Mian M. Shahzad Heather S. L. Jim Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies Cancers gynecologic cancer physical activity sleep inflammation |
| title | Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies |
| title_full | Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies |
| title_fullStr | Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies |
| title_full_unstemmed | Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies |
| title_short | Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies |
| title_sort | relationships among inflammatory biomarkers and objectively assessed physical activity and sleep during and after chemotherapy for gynecologic malignancies |
| topic | gynecologic cancer physical activity sleep inflammation |
| url | https://www.mdpi.com/2072-6694/15/15/3882 |
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