Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method
Dielectric relaxation method has been proposed for the possibility of real-time detection of thrombosis by exploiting the electrical properties of the blood. In-vitro experiments were conducted with bovine blood to measure relative permittivity and dielectric loss in the case of various hematocrit v...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Japanese |
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The Japan Society of Mechanical Engineers
2014-08-01
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| Series: | Nihon Kikai Gakkai ronbunshu |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/transjsme/80/816/80_2014bms0245/_pdf/-char/en |
| _version_ | 1797989051427454976 |
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| author | Yuta ASAKURA Achyut SAPKOTA Osamu MARUYAMA Ryo KOSAKA Takashi YAMANE Masahiro TAKEI |
| author_facet | Yuta ASAKURA Achyut SAPKOTA Osamu MARUYAMA Ryo KOSAKA Takashi YAMANE Masahiro TAKEI |
| author_sort | Yuta ASAKURA |
| collection | DOAJ |
| description | Dielectric relaxation method has been proposed for the possibility of real-time detection of thrombosis by exploiting the electrical properties of the blood. In-vitro experiments were conducted with bovine blood to measure relative permittivity and dielectric loss in the case of various hematocrit values under static blood condition. As a result, the relaxation frequency of the electrode and red blood cells were observed at 20 kHz and 2 MHz respectively. The characteristics frequency showing the permittivity of the red blood cells membrane was in the range of 60 kHz to 1 MHz. The time variations of resistivity and relative permittivity were observed at this frequency range of characteristics frequency of red blood cell membrane. Resistivity and relative permittivity measured at this frequency range increased in the case of the increase in the hematocrit values. Additionally, a peak was observed in the temporal change in relative permittivity only in the case of that frequency range. Moreover, from the results of visual check of thrombosis, this peak indicated the start of the micro-thrombus formation. This phenomenon was specific to the thrombosis, and was observed only in the presence of red blood cells. The experiments showed the possibility of the real time detection of thrombosis for implantable ventricular assistance devices, heart-lung machines and artificial kidney. |
| first_indexed | 2024-04-11T08:14:06Z |
| format | Article |
| id | doaj.art-c35bea0920c3414eac89fc27d64f9ffa |
| institution | Directory Open Access Journal |
| issn | 2187-9761 |
| language | Japanese |
| last_indexed | 2024-04-11T08:14:06Z |
| publishDate | 2014-08-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Nihon Kikai Gakkai ronbunshu |
| spelling | doaj.art-c35bea0920c3414eac89fc27d64f9ffa2022-12-22T04:35:14ZjpnThe Japan Society of Mechanical EngineersNihon Kikai Gakkai ronbunshu2187-97612014-08-0180816BMS0245BMS024510.1299/transjsme.2014bms0245transjsmeMeasurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation methodYuta ASAKURA0Achyut SAPKOTA1Osamu MARUYAMA2Ryo KOSAKA3Takashi YAMANE4Masahiro TAKEI5Division of Artificial Systems Science, Graduate Course of Mechanical Engineering, Chiba UniversityDivision of Artificial Systems Science, Graduate Course of Mechanical Engineering, Chiba UniversityNational Institute of Advanced Industrial Science and TechnologyNational Institute of Advanced Industrial Science and TechnologyDepartment of Mechanical Engineering, Graduate school of Engineering, Kobe UniversityDivision of Artificial Systems Science, Graduate Course of Mechanical Engineering, Chiba UniversityDielectric relaxation method has been proposed for the possibility of real-time detection of thrombosis by exploiting the electrical properties of the blood. In-vitro experiments were conducted with bovine blood to measure relative permittivity and dielectric loss in the case of various hematocrit values under static blood condition. As a result, the relaxation frequency of the electrode and red blood cells were observed at 20 kHz and 2 MHz respectively. The characteristics frequency showing the permittivity of the red blood cells membrane was in the range of 60 kHz to 1 MHz. The time variations of resistivity and relative permittivity were observed at this frequency range of characteristics frequency of red blood cell membrane. Resistivity and relative permittivity measured at this frequency range increased in the case of the increase in the hematocrit values. Additionally, a peak was observed in the temporal change in relative permittivity only in the case of that frequency range. Moreover, from the results of visual check of thrombosis, this peak indicated the start of the micro-thrombus formation. This phenomenon was specific to the thrombosis, and was observed only in the presence of red blood cells. The experiments showed the possibility of the real time detection of thrombosis for implantable ventricular assistance devices, heart-lung machines and artificial kidney.https://www.jstage.jst.go.jp/article/transjsme/80/816/80_2014bms0245/_pdf/-char/endielectric relaxation methodrelaxation frequencythrombus formationred blood cellartificial heart |
| spellingShingle | Yuta ASAKURA Achyut SAPKOTA Osamu MARUYAMA Ryo KOSAKA Takashi YAMANE Masahiro TAKEI Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method Nihon Kikai Gakkai ronbunshu dielectric relaxation method relaxation frequency thrombus formation red blood cell artificial heart |
| title | Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method |
| title_full | Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method |
| title_fullStr | Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method |
| title_full_unstemmed | Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method |
| title_short | Measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method |
| title_sort | measurement of characteristic frequency of red blood cells and thrombogenic process for various hematocrit values using dielectric relaxation method |
| topic | dielectric relaxation method relaxation frequency thrombus formation red blood cell artificial heart |
| url | https://www.jstage.jst.go.jp/article/transjsme/80/816/80_2014bms0245/_pdf/-char/en |
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