Screening of the NIH Clinical Collection for inhibitors of HIV-1 integrase activity

Screening of the NIH Clinical Collection for inhibitors of HIV-1 integrase activity

Drug repurposing offers a validated approach to reduce drug attrition within the drug discovery and development pipeline through the application of known drugs and drug candidates to treat new indications. Full exploitation of this strategy necessitates the screening of a vast number of molecules ag...

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Bibliographic Details
Main Authors: Shaakira Abrahams, Salerwe Mosebi, Muhammed Q. Fish, Maria A. Papathanasopoulos, Raymond Hewer
Format: Article
Language:English
Published: Academy of Science of South Africa 2018-03-01
Series:South African Journal of Science
Subjects:
drug repurposing
strand transfer
pan-assay interference compounds
PAINS
Online Access:https://www.sajs.co.za/article/view/4822

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