Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies
Titanium and alloy osseointegrated implants are used to replace missing teeth; however, some fail and are removed. Modifications of the implant surface with biologically active substances have been proposed. MEDLINE [via Pubmed], Embase and Web of Science were searched with the terms “titanium denta...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.986112/full |
| _version_ | 1818017565124853760 |
|---|---|
| author | Nansi López-Valverde Javier Aragoneses Antonio López-Valverde Antonio López-Valverde Norberto Quispe-López Cinthia Rodríguez Juan Manuel Aragoneses |
| author_facet | Nansi López-Valverde Javier Aragoneses Antonio López-Valverde Antonio López-Valverde Norberto Quispe-López Cinthia Rodríguez Juan Manuel Aragoneses |
| author_sort | Nansi López-Valverde |
| collection | DOAJ |
| description | Titanium and alloy osseointegrated implants are used to replace missing teeth; however, some fail and are removed. Modifications of the implant surface with biologically active substances have been proposed. MEDLINE [via Pubmed], Embase and Web of Science were searched with the terms “titanium dental implants”, “surface properties”, “bioactive surface modifications”, “biomolecules”, “BMP”, “antibacterial agent”, “peptide”, “collagen”, “grown factor”, “osseointegration”, “bone apposition”, “osteogenic”, “osteogenesis”, “new bone formation”, “bone to implant contact”, “bone regeneration” and “in vivo studies”, until May 2022. A total of 10,697 references were iden-tified and 26 were included to analyze 1,109 implants, with follow-ups from 2 to 84 weeks. The ARRIVE guidelines and the SYRCLE tool were used to evaluate the methodology and scientific evidence. A meta-analysis was performed (RevMan 2020 software, Cochane Collaboration) with random effects that evaluated BIC at 4 weeks, with subgroups for the different coatings. The heterogeneity of the pooled studies was very high (95% CI, I2 = 99%). The subgroup of BMPs was the most favorable to coating. Surface modification of Ti implants by organic bioactive molecules seems to favor osseointegration in the early stages of healing, but long-term studies are necessary to corroborate the results of the experimental studies. |
| first_indexed | 2024-04-14T07:28:35Z |
| format | Article |
| id | doaj.art-c35d680c9eb1496998d14881c9b3ad55 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-14T07:28:35Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-c35d680c9eb1496998d14881c9b3ad552022-12-22T02:05:56ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.986112986112Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studiesNansi López-Valverde0Javier Aragoneses1Antonio López-Valverde2Antonio López-Valverde3Norberto Quispe-López4Cinthia Rodríguez5Juan Manuel Aragoneses6Department of Medicine and Medical Specialties, Faculty of Health Sciences, Universidad Alcalá de Henares, Madrid, SpainDepartment of Medicine and Medical Specialties, Faculty of Health Sciences, Universidad Alcalá de Henares, Madrid, SpainDepartment of Surgery, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, Salamanca, SpainDepartment of Dentistry, Universidad Federico Henríquez y Carvajal, Santo Domingo, Dominican RepublicDepartment of Surgery, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, Salamanca, SpainDepartment of Dentistry, Universidad Federico Henríquez y Carvajal, Santo Domingo, Dominican RepublicFaculty of Dentistry, Universidad Alfonso X El Sabio, Madrid, SpainTitanium and alloy osseointegrated implants are used to replace missing teeth; however, some fail and are removed. Modifications of the implant surface with biologically active substances have been proposed. MEDLINE [via Pubmed], Embase and Web of Science were searched with the terms “titanium dental implants”, “surface properties”, “bioactive surface modifications”, “biomolecules”, “BMP”, “antibacterial agent”, “peptide”, “collagen”, “grown factor”, “osseointegration”, “bone apposition”, “osteogenic”, “osteogenesis”, “new bone formation”, “bone to implant contact”, “bone regeneration” and “in vivo studies”, until May 2022. A total of 10,697 references were iden-tified and 26 were included to analyze 1,109 implants, with follow-ups from 2 to 84 weeks. The ARRIVE guidelines and the SYRCLE tool were used to evaluate the methodology and scientific evidence. A meta-analysis was performed (RevMan 2020 software, Cochane Collaboration) with random effects that evaluated BIC at 4 weeks, with subgroups for the different coatings. The heterogeneity of the pooled studies was very high (95% CI, I2 = 99%). The subgroup of BMPs was the most favorable to coating. Surface modification of Ti implants by organic bioactive molecules seems to favor osseointegration in the early stages of healing, but long-term studies are necessary to corroborate the results of the experimental studies.https://www.frontiersin.org/articles/10.3389/fbioe.2022.986112/fulltitanium dental implantsbioactive surface modificationsbiomoleculespeptidesbone morphogenetic proteingrown factor |
| spellingShingle | Nansi López-Valverde Javier Aragoneses Antonio López-Valverde Antonio López-Valverde Norberto Quispe-López Cinthia Rodríguez Juan Manuel Aragoneses Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies Frontiers in Bioengineering and Biotechnology titanium dental implants bioactive surface modifications biomolecules peptides bone morphogenetic protein grown factor |
| title | Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies |
| title_full | Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies |
| title_fullStr | Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies |
| title_full_unstemmed | Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies |
| title_short | Effectiveness of biomolecule-based bioactive surfaces, on os-seointegration of titanium dental implants: A systematic review and meta-analysis of in vivo studies |
| title_sort | effectiveness of biomolecule based bioactive surfaces on os seointegration of titanium dental implants a systematic review and meta analysis of in vivo studies |
| topic | titanium dental implants bioactive surface modifications biomolecules peptides bone morphogenetic protein grown factor |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.986112/full |
| work_keys_str_mv | AT nansilopezvalverde effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies AT javieraragoneses effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies AT antoniolopezvalverde effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies AT antoniolopezvalverde effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies AT norbertoquispelopez effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies AT cinthiarodriguez effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies AT juanmanuelaragoneses effectivenessofbiomoleculebasedbioactivesurfacesonosseointegrationoftitaniumdentalimplantsasystematicreviewandmetaanalysisofinvivostudies |