Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study
Objective: Despite advances made in the treatment of ischemic stroke, it still remains one of the leading causes of mortality and disability worldwide. The main objective of this study was to identify from a panel of 10 inflammatory markers and chemokines those biomarkers that have a potential predi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=4;spage=496;epage=503;aulast=Hutanu |
| _version_ | 1818539328727416832 |
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| author | Adina Hutanu Mihaela Iancu Smaranda Maier Rodica Balasa Minodora Dobreanu |
| author_facet | Adina Hutanu Mihaela Iancu Smaranda Maier Rodica Balasa Minodora Dobreanu |
| author_sort | Adina Hutanu |
| collection | DOAJ |
| description | Objective: Despite advances made in the treatment of ischemic stroke, it still remains one of the leading causes of mortality and disability worldwide. The main objective of this study was to identify from a panel of 10 inflammatory markers and chemokines those biomarkers that have a potential predictive role in the evolution of disability and functional dependence in daily activities after an ischemic stroke. Methods: The study included 116 patients with ischemic stroke and 40 healthy volunteers matched for gender and age. Stroke severity was assessed by the National Institute of Health Stroke Scale (NIHSS) on admission and during hospitalization and functional mobility in daily activities by Barthel index (BI). Multiplex panel with 10 biomarkers [brain-derived neurotrophic factor (BDNF), platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, neural cell adhesion molecule (NCAM), cathepsin D, soluble vascular cell adhesion molecule (sVCAM), soluble intercellular cell adhesion molecule (sICAM), myeloperoxidase (MPO), regulated on activation, normal T cell expressed and secreted (RANTES), plasminogen activator inhibitor (PAI)-1] was analyzed on days 1 and 5 after admission using the xMAP technology. Results: Plasma concentrations of RANTES and NCAM were significantly lower in patients with ischemic stroke compared with healthy controls, while MPO and sICAM were significantly higher in patients versus controls. Plasma concentrations of sICAM, sVCAM, and RANTES significantly decreased during the analyzed period. For the first-day measurement, the bivariate analysis revealed the association of NIHSS on admission with sVCAM, and on discharge negative association with PDGF-AA, PDGR-AB/BB, BDNF, and RANTES. Plasma levels of PDGF-AA, PDGF-AB/BB, BDNF, and RANTES were found to be significantly lower in patients with BI ≤ 80, on day 5 after disease onset. PDGF-AA, PDGF-AB/BB, and BDNF were univariate and multivariate predictors for functional dependence in daily life activity (BI ≤ 80), having a protective effect (odds ratio < 1). Conclusion: Plasma levels of BDNF, PDGF-AA, and PDGF-AB/BB are independent predictors for functional dependency in daily life activities and may be useful prognostic markers in the evaluation of ischemic stroke patients. |
| first_indexed | 2024-12-11T21:40:36Z |
| format | Article |
| id | doaj.art-c35e8162fc7b4a839f0204a62301eb0e |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-11T21:40:36Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-c35e8162fc7b4a839f0204a62301eb0e2022-12-22T00:49:52ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492020-01-0123449650310.4103/aian.AIAN_74_19Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center studyAdina HutanuMihaela IancuSmaranda MaierRodica BalasaMinodora DobreanuObjective: Despite advances made in the treatment of ischemic stroke, it still remains one of the leading causes of mortality and disability worldwide. The main objective of this study was to identify from a panel of 10 inflammatory markers and chemokines those biomarkers that have a potential predictive role in the evolution of disability and functional dependence in daily activities after an ischemic stroke. Methods: The study included 116 patients with ischemic stroke and 40 healthy volunteers matched for gender and age. Stroke severity was assessed by the National Institute of Health Stroke Scale (NIHSS) on admission and during hospitalization and functional mobility in daily activities by Barthel index (BI). Multiplex panel with 10 biomarkers [brain-derived neurotrophic factor (BDNF), platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, neural cell adhesion molecule (NCAM), cathepsin D, soluble vascular cell adhesion molecule (sVCAM), soluble intercellular cell adhesion molecule (sICAM), myeloperoxidase (MPO), regulated on activation, normal T cell expressed and secreted (RANTES), plasminogen activator inhibitor (PAI)-1] was analyzed on days 1 and 5 after admission using the xMAP technology. Results: Plasma concentrations of RANTES and NCAM were significantly lower in patients with ischemic stroke compared with healthy controls, while MPO and sICAM were significantly higher in patients versus controls. Plasma concentrations of sICAM, sVCAM, and RANTES significantly decreased during the analyzed period. For the first-day measurement, the bivariate analysis revealed the association of NIHSS on admission with sVCAM, and on discharge negative association with PDGF-AA, PDGR-AB/BB, BDNF, and RANTES. Plasma levels of PDGF-AA, PDGF-AB/BB, BDNF, and RANTES were found to be significantly lower in patients with BI ≤ 80, on day 5 after disease onset. PDGF-AA, PDGF-AB/BB, and BDNF were univariate and multivariate predictors for functional dependence in daily life activity (BI ≤ 80), having a protective effect (odds ratio < 1). Conclusion: Plasma levels of BDNF, PDGF-AA, and PDGF-AB/BB are independent predictors for functional dependency in daily life activities and may be useful prognostic markers in the evaluation of ischemic stroke patients.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=4;spage=496;epage=503;aulast=Hutanubarthel indexbdnfblood biomarkerpai-1pdgfrantesstrokeneurotrophins |
| spellingShingle | Adina Hutanu Mihaela Iancu Smaranda Maier Rodica Balasa Minodora Dobreanu Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study Annals of Indian Academy of Neurology barthel index bdnf blood biomarker pai-1 pdgf rantes stroke neurotrophins |
| title | Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study |
| title_full | Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study |
| title_fullStr | Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study |
| title_full_unstemmed | Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study |
| title_short | Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study |
| title_sort | plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke a single center study |
| topic | barthel index bdnf blood biomarker pai-1 pdgf rantes stroke neurotrophins |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=4;spage=496;epage=503;aulast=Hutanu |
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