Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors
Abstract Background Patient-reported outcomes (PROs) play a crucial role in assessing rheumatic diseases, offering insights into disease evaluation and treatment efficacy. This study focuses on PRO assessment in large vessel vasculitides, including Takayasu Arteritis and Giant Cell Arteritis (GCA)....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | Journal of Patient-Reported Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41687-023-00681-w |
| _version_ | 1797274467726000128 |
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| author | A. Kernder M. Rohde H. Acar C. Düsing R. Fischer-Betz I. Haase J. Mucke O. Sander J. G. Richter T. Filla M. Schneider G. Chehab |
| author_facet | A. Kernder M. Rohde H. Acar C. Düsing R. Fischer-Betz I. Haase J. Mucke O. Sander J. G. Richter T. Filla M. Schneider G. Chehab |
| author_sort | A. Kernder |
| collection | DOAJ |
| description | Abstract Background Patient-reported outcomes (PROs) play a crucial role in assessing rheumatic diseases, offering insights into disease evaluation and treatment efficacy. This study focuses on PRO assessment in large vessel vasculitides, including Takayasu Arteritis and Giant Cell Arteritis (GCA). Methods We retrospectively analyzed routine data from patients treated at our rheumatology clinic over a 10-year span. Patient and physician-rated global disease activity scale (G-DAS) scores, measured on a numeric rating scale (0–10 points), were collected at each visit. Clinical variables like age, sex, body mass index (BMI), disease duration, lab values, pain perception, and questionnaire responses were recorded. Linear regression and generalized additive linear regression (GAM analysis) examined associations between PROs and these factors. Results The study included 138 patients, primarily diagnosed with GCA (94.4%). Mean follow-up was 2.5 years (0-7.7). Patient and physician G-DAS exhibited a moderate correlation (Pearson R 0.19, CI 0.14–0.24, p < 0.001). Higher patient G-DAS correlated with younger age (CI -3.4 - -1.5, p < 0.001), increased pain (CI 3.5-4, p < 0.001), functional limitations (HAQ, CI 0.5–0.6, p < 0.001), reduced physical (CI 2.3–2.7, p ≤ 0.001) and psychological well-being (CI 2.1–2.5, p < 0.001), and higher BMI (CI 1.3–2.4, p < 0.001). Physician G-DAS correlated with Birmingham Vasculitis Activity Score (V3.0; R 0.42, p 0.046) and were significantly linked to serum CRP elevations (β = 0.04, CI 0.0-0.08, p 0.028). Conclusions These findings underscore the need to integrate PRO measures into vasculitis disease management strategies, enhancing the understanding of disease activity from the patient’s perspective. |
| first_indexed | 2024-03-07T14:58:47Z |
| format | Article |
| id | doaj.art-c36042bcc4984752b2b87bab831de557 |
| institution | Directory Open Access Journal |
| issn | 2509-8020 |
| language | English |
| last_indexed | 2024-03-07T14:58:47Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Patient-Reported Outcomes |
| spelling | doaj.art-c36042bcc4984752b2b87bab831de5572024-03-05T19:17:32ZengSpringerOpenJournal of Patient-Reported Outcomes2509-80202024-01-01811710.1186/s41687-023-00681-wPatient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factorsA. Kernder0M. Rohde1H. Acar2C. Düsing3R. Fischer-Betz4I. Haase5J. Mucke6O. Sander7J. G. Richter8T. Filla9M. Schneider10G. Chehab11Department of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityDepartment of Rheumatology, Medical Faculty of Heinrich, University Hospital Düsseldorf, Heine UniversityAbstract Background Patient-reported outcomes (PROs) play a crucial role in assessing rheumatic diseases, offering insights into disease evaluation and treatment efficacy. This study focuses on PRO assessment in large vessel vasculitides, including Takayasu Arteritis and Giant Cell Arteritis (GCA). Methods We retrospectively analyzed routine data from patients treated at our rheumatology clinic over a 10-year span. Patient and physician-rated global disease activity scale (G-DAS) scores, measured on a numeric rating scale (0–10 points), were collected at each visit. Clinical variables like age, sex, body mass index (BMI), disease duration, lab values, pain perception, and questionnaire responses were recorded. Linear regression and generalized additive linear regression (GAM analysis) examined associations between PROs and these factors. Results The study included 138 patients, primarily diagnosed with GCA (94.4%). Mean follow-up was 2.5 years (0-7.7). Patient and physician G-DAS exhibited a moderate correlation (Pearson R 0.19, CI 0.14–0.24, p < 0.001). Higher patient G-DAS correlated with younger age (CI -3.4 - -1.5, p < 0.001), increased pain (CI 3.5-4, p < 0.001), functional limitations (HAQ, CI 0.5–0.6, p < 0.001), reduced physical (CI 2.3–2.7, p ≤ 0.001) and psychological well-being (CI 2.1–2.5, p < 0.001), and higher BMI (CI 1.3–2.4, p < 0.001). Physician G-DAS correlated with Birmingham Vasculitis Activity Score (V3.0; R 0.42, p 0.046) and were significantly linked to serum CRP elevations (β = 0.04, CI 0.0-0.08, p 0.028). Conclusions These findings underscore the need to integrate PRO measures into vasculitis disease management strategies, enhancing the understanding of disease activity from the patient’s perspective.https://doi.org/10.1186/s41687-023-00681-wPatient-reported outcomes (PROs)Disease activityGiant cell arteritisLarge vessel vasculitisTakayasu arteriitis |
| spellingShingle | A. Kernder M. Rohde H. Acar C. Düsing R. Fischer-Betz I. Haase J. Mucke O. Sander J. G. Richter T. Filla M. Schneider G. Chehab Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors Journal of Patient-Reported Outcomes Patient-reported outcomes (PROs) Disease activity Giant cell arteritis Large vessel vasculitis Takayasu arteriitis |
| title | Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors |
| title_full | Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors |
| title_fullStr | Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors |
| title_full_unstemmed | Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors |
| title_short | Patient-reported outcomes in large vessel vasculitis: insights from a retrospective analysis of disease activity and associated factors |
| title_sort | patient reported outcomes in large vessel vasculitis insights from a retrospective analysis of disease activity and associated factors |
| topic | Patient-reported outcomes (PROs) Disease activity Giant cell arteritis Large vessel vasculitis Takayasu arteriitis |
| url | https://doi.org/10.1186/s41687-023-00681-w |
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