Chronic Liver Diseases in Children: Clinical Profile and Histology
Aim: The main aim of the study is to study the clinical profile of disorders of the liver and hepatobiliary system in paediatric patients and to correlate the histopathology findings of liver biopsy in chronic liver disease. Another aim being to assess the prognosis and to know the outcome and t...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6250/13383_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1811248100476452864 |
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| author | Sachin Devidas Dhole Archana S. Kher Radha G. Ghildiyal Manjusha P. Tambse |
| author_facet | Sachin Devidas Dhole Archana S. Kher Radha G. Ghildiyal Manjusha P. Tambse |
| author_sort | Sachin Devidas Dhole |
| collection | DOAJ |
| description | Aim: The main aim of the study is to study the clinical profile
of disorders of the liver and hepatobiliary system in paediatric
patients and to correlate the histopathology findings of liver
biopsy in chronic liver disease. Another aim being to assess the
prognosis and to know the outcome and the effects of treatment
in chronic liver diseases in paediatric age group.
Materials and Methods: It was a prospective study, included
the clinical profile of Chronic Liver Diseases (CLD) in children
and the histopathological correlation. A total of 55 children were
thoroughly investigated by doing relevant investigations and
liver biopsy.
Observations and Results: A male predominance (60%)
was noted with maximum incidence in the age group of 6-12
years. The incidence of CLD was 1.1% of total admissions.
The most common presenting complaint was jaundice and
abdominal distension. Hepatic encephalopathy was noted in
29% patients. Hepatomegaly was seen in 63% patients and
spleenomegaly was seen in 60% patients. The incidence of
cirrhosis on liver biopsy was 42% (23cases) in CLD patients.
The most common diagnosis on histopathology was Wilson’s
disease (22%), followed by hepatitis and autoimmune hepatitis.
The predominant spectrum of CLD was metabolic liver disease
and also the predominant cause of death.
Conclusion: As the incidence of CLD is quite low, a very
high index of suspicion is required for its diagnosis. Some
uncommon causes of CLD in children were seen in our study
like neutral lipid storage disease, α1-Antitrypsin deficiency
disease, lupus hepatitis, Alagille syndrome and Budd-Chiari
syndrome. A patient of CLD with jaundice and hepatomegaly
should be treated aggressively as those are the poor prognostic
indicators of the disease. Hepatic encephalopathy and cirrhosis
are also associated with poor outcome in patients with CLD.
Liver biopsy histopathology by an expert and its correlation
with laboratory investigations plays an important role in the
diagnosis of CLD. The major cause of deaths in patients with
CLD is due to end stage liver disease and fulminant hepatic
failure and the only way to prevent and treat these patients is by
liver transplantation. |
| first_indexed | 2024-04-12T15:20:56Z |
| format | Article |
| id | doaj.art-c3617a966d7c4765b360ee190dcdb714 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-12T15:20:56Z |
| publishDate | 2015-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-c3617a966d7c4765b360ee190dcdb7142022-12-22T03:27:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-07-0197SC04SC0710.7860/JCDR/2015/13383.6250Chronic Liver Diseases in Children: Clinical Profile and HistologySachin Devidas Dhole0Archana S. Kher1Radha G. Ghildiyal2Manjusha P. Tambse3Assistant Professor, Department of Pediatrics, A.C.P.M. Medical College, Dhule, Maharashtra, India.Consulting Pediatrician, Department of Pediatrics, Columbia/ Asia Hospital, Pune, Maharashtra, India.Professor, Department of Pediatrics, T.N. Medical College, Mumbai, Maharashtra, India.Assistant Professor, Department of Pathology, S.B.H. Government Medical College, Dhule, Maharashtra, India.Aim: The main aim of the study is to study the clinical profile of disorders of the liver and hepatobiliary system in paediatric patients and to correlate the histopathology findings of liver biopsy in chronic liver disease. Another aim being to assess the prognosis and to know the outcome and the effects of treatment in chronic liver diseases in paediatric age group. Materials and Methods: It was a prospective study, included the clinical profile of Chronic Liver Diseases (CLD) in children and the histopathological correlation. A total of 55 children were thoroughly investigated by doing relevant investigations and liver biopsy. Observations and Results: A male predominance (60%) was noted with maximum incidence in the age group of 6-12 years. The incidence of CLD was 1.1% of total admissions. The most common presenting complaint was jaundice and abdominal distension. Hepatic encephalopathy was noted in 29% patients. Hepatomegaly was seen in 63% patients and spleenomegaly was seen in 60% patients. The incidence of cirrhosis on liver biopsy was 42% (23cases) in CLD patients. The most common diagnosis on histopathology was Wilson’s disease (22%), followed by hepatitis and autoimmune hepatitis. The predominant spectrum of CLD was metabolic liver disease and also the predominant cause of death. Conclusion: As the incidence of CLD is quite low, a very high index of suspicion is required for its diagnosis. Some uncommon causes of CLD in children were seen in our study like neutral lipid storage disease, α1-Antitrypsin deficiency disease, lupus hepatitis, Alagille syndrome and Budd-Chiari syndrome. A patient of CLD with jaundice and hepatomegaly should be treated aggressively as those are the poor prognostic indicators of the disease. Hepatic encephalopathy and cirrhosis are also associated with poor outcome in patients with CLD. Liver biopsy histopathology by an expert and its correlation with laboratory investigations plays an important role in the diagnosis of CLD. The major cause of deaths in patients with CLD is due to end stage liver disease and fulminant hepatic failure and the only way to prevent and treat these patients is by liver transplantation.https://jcdr.net/articles/PDF/6250/13383_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfcldliver biopsymetabolic liver disease |
| spellingShingle | Sachin Devidas Dhole Archana S. Kher Radha G. Ghildiyal Manjusha P. Tambse Chronic Liver Diseases in Children: Clinical Profile and Histology Journal of Clinical and Diagnostic Research cld liver biopsy metabolic liver disease |
| title | Chronic Liver Diseases in Children: Clinical Profile and Histology |
| title_full | Chronic Liver Diseases in Children: Clinical Profile and Histology |
| title_fullStr | Chronic Liver Diseases in Children: Clinical Profile and Histology |
| title_full_unstemmed | Chronic Liver Diseases in Children: Clinical Profile and Histology |
| title_short | Chronic Liver Diseases in Children: Clinical Profile and Histology |
| title_sort | chronic liver diseases in children clinical profile and histology |
| topic | cld liver biopsy metabolic liver disease |
| url | https://jcdr.net/articles/PDF/6250/13383_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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