Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary

Abstract Background Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to establish the risk factors of RIA in t...

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Main Authors: Yerkin Medetov, Aisha Babi, Yerbol Makhambetov, Karashash Menlibayeva, Torekhan Bex, Assylbek Kaliyev, Serik Akshulakov
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Neurology
Subjects:
Online Access:https://doi.org/10.1186/s12883-022-02892-y
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author Yerkin Medetov
Aisha Babi
Yerbol Makhambetov
Karashash Menlibayeva
Torekhan Bex
Assylbek Kaliyev
Serik Akshulakov
author_facet Yerkin Medetov
Aisha Babi
Yerbol Makhambetov
Karashash Menlibayeva
Torekhan Bex
Assylbek Kaliyev
Serik Akshulakov
author_sort Yerkin Medetov
collection DOAJ
description Abstract Background Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to establish the risk factors of RIA in the Kazakh population.  Methods Retrospective analysis of 762 patients with single IAs, who attended the neurosurgical center from 2008 until 2018, was conducted. Demographic characteristics, such as age, sex, smoking status, and hypertension were considered. Descriptive and bivariate analyses were performed. A multivariable logistic regression model was built to identify factors correlated with RIA. Results The mean age of participants was 48.49 ± 0.44 years old. The majority (68.37%) of IAs have ruptured. Of the ruptured aneurysms, 43.76% were < 6 mm, and 38.39% were located on the anterior cerebral and anterior communicating arteries (ACA). Logistic regression model indicates younger age group (16–40 years), smoking, having stage 3 hypertension, smaller IA size and its location on ACA increase the odds of rupture. Conclusions This study has revealed that younger, smoking patients with stage 3 arterial hypertension are at higher risk for RIA. Small aneurysms (< 6 mm) and location on ACA had increased odds of rupture, while larger aneurysms on internal carotid arteries had lower odds.
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spelling doaj.art-c365d1a21acf44c6b0b9ed5c68282f932022-12-22T04:25:55ZengBMCBMC Neurology1471-23772022-09-012211710.1186/s12883-022-02892-yRisk factors for aneurysm rupture among Kazakhs: findings from a national tertiaryYerkin Medetov0Aisha Babi1Yerbol Makhambetov2Karashash Menlibayeva3Torekhan Bex4Assylbek Kaliyev5Serik Akshulakov6Department of Vascular and Functional Neurosurgery, National Center for NeurosurgeryHospital Management Department, National Center for NeurosurgeryDepartment of Vascular and Functional Neurosurgery, National Center for NeurosurgeryHospital Management Department, National Center for NeurosurgeryHospital Management Department, National Center for NeurosurgeryDepartment of Vascular and Functional Neurosurgery, National Center for NeurosurgeryDepartment of Vascular and Functional Neurosurgery, National Center for NeurosurgeryAbstract Background Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to establish the risk factors of RIA in the Kazakh population.  Methods Retrospective analysis of 762 patients with single IAs, who attended the neurosurgical center from 2008 until 2018, was conducted. Demographic characteristics, such as age, sex, smoking status, and hypertension were considered. Descriptive and bivariate analyses were performed. A multivariable logistic regression model was built to identify factors correlated with RIA. Results The mean age of participants was 48.49 ± 0.44 years old. The majority (68.37%) of IAs have ruptured. Of the ruptured aneurysms, 43.76% were < 6 mm, and 38.39% were located on the anterior cerebral and anterior communicating arteries (ACA). Logistic regression model indicates younger age group (16–40 years), smoking, having stage 3 hypertension, smaller IA size and its location on ACA increase the odds of rupture. Conclusions This study has revealed that younger, smoking patients with stage 3 arterial hypertension are at higher risk for RIA. Small aneurysms (< 6 mm) and location on ACA had increased odds of rupture, while larger aneurysms on internal carotid arteries had lower odds.https://doi.org/10.1186/s12883-022-02892-yIntracranial aneurysmAneurysm ruptureKazakh populationRisk factors
spellingShingle Yerkin Medetov
Aisha Babi
Yerbol Makhambetov
Karashash Menlibayeva
Torekhan Bex
Assylbek Kaliyev
Serik Akshulakov
Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary
BMC Neurology
Intracranial aneurysm
Aneurysm rupture
Kazakh population
Risk factors
title Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary
title_full Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary
title_fullStr Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary
title_full_unstemmed Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary
title_short Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary
title_sort risk factors for aneurysm rupture among kazakhs findings from a national tertiary
topic Intracranial aneurysm
Aneurysm rupture
Kazakh population
Risk factors
url https://doi.org/10.1186/s12883-022-02892-y
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