Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand
The emergent issue of carbapenem-resistant <i>Acinetobacter baumannii</i> (<i>A</i><i>. baumannii</i>) and <i>Pseudomonas aeruginosa</i> (<i>P</i><i>. aeruginosa</i>) is a major problem in Thailand. The wide use of carbapenems c...
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| Materyal Türü: | Makale |
| Dil: | English |
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MDPI AG
2022-01-01
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| Seri Bilgileri: | Antibiotics |
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| Online Erişim: | https://www.mdpi.com/2079-6382/11/2/143 |
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| author | Taniya Paiboonvong Phatchareeporn Tedtaisong Preecha Montakantikul Sarun Gorsanan Woraphot Tantisiriwat |
| author_facet | Taniya Paiboonvong Phatchareeporn Tedtaisong Preecha Montakantikul Sarun Gorsanan Woraphot Tantisiriwat |
| author_sort | Taniya Paiboonvong |
| collection | DOAJ |
| description | The emergent issue of carbapenem-resistant <i>Acinetobacter baumannii</i> (<i>A</i><i>. baumannii</i>) and <i>Pseudomonas aeruginosa</i> (<i>P</i><i>. aeruginosa</i>) is a major problem in Thailand. The wide use of carbapenems can increase selective pressure of bacterial resistance. The objective of this study was to determine the relationship between carbapenem consumption and the susceptibility rates of <i>A</i><i>. baumannii</i> and <i>P</i><i>. aeruginosa</i>, including multi-drug resistance (MDR) strains. This was a retrospective study. Carbapenem consumption and susceptibility profiles were collected from 2007 to 2013 at the Her Royal Highness Princess Maha Chakri Sirindhorn Medical Center, Thailand. We found that the susceptibility rate of <i>A</i><i>. baumannii</i> to imipenem and meropenem from the sputum and the bronchoalveolar lavage (BAL) specimens was significantly decreased during the study period, but no significant change was found in the <i>P</i><i>. aeruginosa</i> data. The relationship between carbapenem consumption and the susceptibility rate of <i>A</i><i>. baumannii</i> had a clear association with the use of ertapenem. We found a statistically significant negative correlation between ertapenem consumption and the susceptibility rate of <i>A</i><i>. baumannii</i> to imipenem (r = −0.91; <i>p</i> = 0.004) and meropenem (r = −0.97; <i>p</i> = 0.000) in the data from the non-ICU wards. In addition, imipenem use had a moderate negative correlation with the MDR <i>P</i><i>. aeruginosa</i> data but no statistical significance (r = −0.714; <i>p</i> > 0.05). In conclusion, our study suggested there is an association between carbapenem use and the susceptibility of <i>A</i><i>. baumannii</i> and <i>P</i><i>. aeruginosa</i>. Notwithstanding this, information on ecological factors should be considered for further study. These findings showed the need to optimize the carbapenem prescription policy. Avoiding carbapenem overuse and rethinking the appropriate initial therapy might decrease the rate of resistant organisms. |
| first_indexed | 2024-03-09T22:47:45Z |
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| id | doaj.art-c3667ab96a9a43c29afd51d5b398d174 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T22:47:45Z |
| publishDate | 2022-01-01 |
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| series | Antibiotics |
| spelling | doaj.art-c3667ab96a9a43c29afd51d5b398d1742023-11-23T18:27:08ZengMDPI AGAntibiotics2079-63822022-01-0111214310.3390/antibiotics11020143Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in ThailandTaniya Paiboonvong0Phatchareeporn Tedtaisong1Preecha Montakantikul2Sarun Gorsanan3Woraphot Tantisiriwat4Department of Pharmacy Practice, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandDepartment of Pharmacy, HRH Princess Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok 26120, ThailandDivision of Clinical Pharmacy, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandDepartment of Social and Administrative Pharmacy, Faculty of Pharmaceutical Sciences, Huachiew Chalermprakiet University, Samut Prakarn 10540, ThailandDepartment of Preventive Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok 26120, ThailandThe emergent issue of carbapenem-resistant <i>Acinetobacter baumannii</i> (<i>A</i><i>. baumannii</i>) and <i>Pseudomonas aeruginosa</i> (<i>P</i><i>. aeruginosa</i>) is a major problem in Thailand. The wide use of carbapenems can increase selective pressure of bacterial resistance. The objective of this study was to determine the relationship between carbapenem consumption and the susceptibility rates of <i>A</i><i>. baumannii</i> and <i>P</i><i>. aeruginosa</i>, including multi-drug resistance (MDR) strains. This was a retrospective study. Carbapenem consumption and susceptibility profiles were collected from 2007 to 2013 at the Her Royal Highness Princess Maha Chakri Sirindhorn Medical Center, Thailand. We found that the susceptibility rate of <i>A</i><i>. baumannii</i> to imipenem and meropenem from the sputum and the bronchoalveolar lavage (BAL) specimens was significantly decreased during the study period, but no significant change was found in the <i>P</i><i>. aeruginosa</i> data. The relationship between carbapenem consumption and the susceptibility rate of <i>A</i><i>. baumannii</i> had a clear association with the use of ertapenem. We found a statistically significant negative correlation between ertapenem consumption and the susceptibility rate of <i>A</i><i>. baumannii</i> to imipenem (r = −0.91; <i>p</i> = 0.004) and meropenem (r = −0.97; <i>p</i> = 0.000) in the data from the non-ICU wards. In addition, imipenem use had a moderate negative correlation with the MDR <i>P</i><i>. aeruginosa</i> data but no statistical significance (r = −0.714; <i>p</i> > 0.05). In conclusion, our study suggested there is an association between carbapenem use and the susceptibility of <i>A</i><i>. baumannii</i> and <i>P</i><i>. aeruginosa</i>. Notwithstanding this, information on ecological factors should be considered for further study. These findings showed the need to optimize the carbapenem prescription policy. Avoiding carbapenem overuse and rethinking the appropriate initial therapy might decrease the rate of resistant organisms.https://www.mdpi.com/2079-6382/11/2/143carbapenem consumption<i>A. baumannii</i><i>P. aeruginosa</i>multidrug-resistant <i>A. baumannii</i>multidrug-resistant <i>P. aeruginosa</i> |
| spellingShingle | Taniya Paiboonvong Phatchareeporn Tedtaisong Preecha Montakantikul Sarun Gorsanan Woraphot Tantisiriwat Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand Antibiotics carbapenem consumption <i>A. baumannii</i> <i>P. aeruginosa</i> multidrug-resistant <i>A. baumannii</i> multidrug-resistant <i>P. aeruginosa</i> |
| title | Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand |
| title_full | Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand |
| title_fullStr | Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand |
| title_full_unstemmed | Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand |
| title_short | Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in an Academic Medical Center in Thailand |
| title_sort | correlation between carbapenem consumption and carbapenems susceptibility profiles of i acinetobacter baumannii i and i pseudomonas aeruginosa i in an academic medical center in thailand |
| topic | carbapenem consumption <i>A. baumannii</i> <i>P. aeruginosa</i> multidrug-resistant <i>A. baumannii</i> multidrug-resistant <i>P. aeruginosa</i> |
| url | https://www.mdpi.com/2079-6382/11/2/143 |
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