Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol

Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol

Clioquinol has been shown to have anticancer activity in several carcinoma cells. In this study, we preliminarily examined the effect of clioquinol in human SMMC-7721 hepatoma and QSG-7701 normal hepatic cells. Our results indicated that clioquinol did not significantly affect survival of QSG-7701 c...

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Bibliographic Details
Main Authors: Huang Zhiwei, Wang Lianqiu, Chen Lifeng, Zhang Yifei, Shi Ping
Format: Article
Language:English
Published: Sciendo 2015-12-01
Series:Acta Pharmaceutica
Subjects:
clioquinol
human smmc-7721 hepatoma cells
cell cycle s-phase arrest
cyclin e/a-cdk2
Online Access:https://doi.org/10.1515/acph-2015-0034

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