The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties
Background: Surgical sutures are sterile filaments to support the healing process. Also Suture as a major part of surgical site management can challenge surgical wound healing. The objective of the current study was to prevent surgical site infection by creating a new antibacterial silk-nano cefixim...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2022-05-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_91948_91aa9bac6f52d9c9d05f8b5fa71dff5b.pdf |
| _version_ | 1797790783026233344 |
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| author | Ali Alirezaie Alavijeh Masoomeh Dadpay Mohammad Barati |
| author_facet | Ali Alirezaie Alavijeh Masoomeh Dadpay Mohammad Barati |
| author_sort | Ali Alirezaie Alavijeh |
| collection | DOAJ |
| description | Background: Surgical sutures are sterile filaments to support the healing process. Also Suture as a major part of surgical site management can challenge surgical wound healing. The objective of the current study was to prevent surgical site infection by creating a new antibacterial silk-nano cefixime suture.Methods: The silk suture became silk-nano cefixime suture by immersing in the 1, 2, and 3 wt % cefixime solutions. The antibacterial activity of silk-nano cefixime suture was tested on E. coli (ATCC25922). The healing effect of silk-nano cefixime suture was evaluated by H&E staining sections and compared between the control and treated groups on days 3, 8 and 14. The obtained quantitative data were presented as mean ± standard deviation. In order to compare the mean of quantitative variables between the studied groups, general linear model of statistical analysis test and 3-D SPSS charts were used (P ≤ 0.05).Results: The inhibition zone diameter of E. coli (ATCC25922) was 25 mm and no statistically significant difference was found between the healing properties (P≥.05). There was a significant difference in the mean of Polymorphonuclear leukocytes (PMN) and macrophage infiltration between the control and treated groups on day 8 (p≤ 0.05).Conclusion: Our data indicate that silk-nano cefixime suture has the potential to reduce the risk of surgical site infections. Finally, it is strongly recommended to introduce silk-nano cefixime suture as a reliable substitute for current surgical sutures. |
| first_indexed | 2024-03-13T02:09:27Z |
| format | Article |
| id | doaj.art-c366fa03b0da4ff3b07a907757cc2263 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:09:27Z |
| publishDate | 2022-05-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-c366fa03b0da4ff3b07a907757cc22632023-07-01T05:10:36ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432022-05-0129324625310.22062/jkmu.2022.9194891948The Effect of Silk-nanocefixime Suture on Healing and Antibacterial PropertiesAli Alirezaie Alavijeh0Masoomeh Dadpay1Mohammad Barati2Clinical Department, Shahrekord University, Shahrekord, IranDepartment of Pathology, Medical Faculty, AJA University of Medical Sciences, Tehran, IranDepartment of Applied Chemistry, Faculty of Chemistry, University of Kashan, Kashan, IranBackground: Surgical sutures are sterile filaments to support the healing process. Also Suture as a major part of surgical site management can challenge surgical wound healing. The objective of the current study was to prevent surgical site infection by creating a new antibacterial silk-nano cefixime suture.Methods: The silk suture became silk-nano cefixime suture by immersing in the 1, 2, and 3 wt % cefixime solutions. The antibacterial activity of silk-nano cefixime suture was tested on E. coli (ATCC25922). The healing effect of silk-nano cefixime suture was evaluated by H&E staining sections and compared between the control and treated groups on days 3, 8 and 14. The obtained quantitative data were presented as mean ± standard deviation. In order to compare the mean of quantitative variables between the studied groups, general linear model of statistical analysis test and 3-D SPSS charts were used (P ≤ 0.05).Results: The inhibition zone diameter of E. coli (ATCC25922) was 25 mm and no statistically significant difference was found between the healing properties (P≥.05). There was a significant difference in the mean of Polymorphonuclear leukocytes (PMN) and macrophage infiltration between the control and treated groups on day 8 (p≤ 0.05).Conclusion: Our data indicate that silk-nano cefixime suture has the potential to reduce the risk of surgical site infections. Finally, it is strongly recommended to introduce silk-nano cefixime suture as a reliable substitute for current surgical sutures.https://jkmu.kmu.ac.ir/article_91948_91aa9bac6f52d9c9d05f8b5fa71dff5b.pdfkeyword: silk suturenano-cefixime trihydrateantibacterial activityhealing properties |
| spellingShingle | Ali Alirezaie Alavijeh Masoomeh Dadpay Mohammad Barati The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties Journal of Kerman University of Medical Sciences keyword: silk suture nano-cefixime trihydrate antibacterial activity healing properties |
| title | The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties |
| title_full | The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties |
| title_fullStr | The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties |
| title_full_unstemmed | The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties |
| title_short | The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties |
| title_sort | effect of silk nanocefixime suture on healing and antibacterial properties |
| topic | keyword: silk suture nano-cefixime trihydrate antibacterial activity healing properties |
| url | https://jkmu.kmu.ac.ir/article_91948_91aa9bac6f52d9c9d05f8b5fa71dff5b.pdf |
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