Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis
Objective: Necrotizing enterocolitis (NEC) is characterized by a rich infiltration of macrophages in the intestines, which is derived from monocytes in the blood. The authors aimed to explore the changing trend of absolute monocyte counts (AMC) over time in NEC infants and to verify whether the redu...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755723000360 |
| _version_ | 1827854935506550784 |
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| author | Zhiru Wang Qingqi Chong Junmei Zhou Tingting Gao Kai Zhu Xiaohui Gong Qingfeng Sheng Zhibao Lv |
| author_facet | Zhiru Wang Qingqi Chong Junmei Zhou Tingting Gao Kai Zhu Xiaohui Gong Qingfeng Sheng Zhibao Lv |
| author_sort | Zhiru Wang |
| collection | DOAJ |
| description | Objective: Necrotizing enterocolitis (NEC) is characterized by a rich infiltration of macrophages in the intestines, which is derived from monocytes in the blood. The authors aimed to explore the changing trend of absolute monocyte counts (AMC) over time in NEC infants and to verify whether the reduction of AMC correlates with the severity of NEC and whether it can be used to identify infants who need surgery. Method: The authors collected the clinical data of 66 control and 222 NEC infants. The NEC infants were divided into medical NEC (M-NEC) and surgical NEC (S-NEC). The counting of monocyte and their percentage change were compared at the time of birth, before NEC (baseline), the onset of NEC and after NEC (recovery). In addition, the same comparison was made among stages 1, 2 and 3 of Bell's staging, respectively. Results: The authors found that the AMC in NEC infants decreased sharply at the onset. Further comparison was made between 172 cases of M-NEC and 50 cases of S-NEC. It was discovered that the AMC reduced more in S-NEC infants at onset, but it increased more at recovery. In addition, the authors found that among stage 1,2 and 3, stage 3 had the lowest AMC and the largest percentage decrease at the onset. Conclusion: The AMC decreases sharply in NEC infants at onset, and the degree of decline is associated with the severity of NEC. AMC is expected to be a marker of NEC and provide a reference for clinicians in the diagnosis and treatment of NEC. |
| first_indexed | 2024-03-12T11:37:45Z |
| format | Article |
| id | doaj.art-c3676d84264a42c1b8285105af5abf6e |
| institution | Directory Open Access Journal |
| issn | 0021-7557 |
| language | English |
| last_indexed | 2024-03-12T11:37:45Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-c3676d84264a42c1b8285105af5abf6e2023-09-01T05:00:35ZengElsevierJornal de Pediatria0021-75572023-09-01995449455Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitisZhiru Wang0Qingqi Chong1Junmei Zhou2Tingting Gao3Kai Zhu4Xiaohui Gong5Qingfeng Sheng6Zhibao Lv7Shanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of General Surgery, Shanghai, ChinaShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of General Surgery, Shanghai, ChinaShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Central Laboratory, Shanghai, ChinaShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of General Surgery, Shanghai, ChinaShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of General Surgery, Shanghai, ChinaShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of Neonatology, Shanghai, ChinaShanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of General Surgery, Shanghai, China; Corresponding authors.Shanghai Jiao Tong University, School of Medicine, Shanghai Children's Hospital, Department of General Surgery, Shanghai, China; Corresponding authors.Objective: Necrotizing enterocolitis (NEC) is characterized by a rich infiltration of macrophages in the intestines, which is derived from monocytes in the blood. The authors aimed to explore the changing trend of absolute monocyte counts (AMC) over time in NEC infants and to verify whether the reduction of AMC correlates with the severity of NEC and whether it can be used to identify infants who need surgery. Method: The authors collected the clinical data of 66 control and 222 NEC infants. The NEC infants were divided into medical NEC (M-NEC) and surgical NEC (S-NEC). The counting of monocyte and their percentage change were compared at the time of birth, before NEC (baseline), the onset of NEC and after NEC (recovery). In addition, the same comparison was made among stages 1, 2 and 3 of Bell's staging, respectively. Results: The authors found that the AMC in NEC infants decreased sharply at the onset. Further comparison was made between 172 cases of M-NEC and 50 cases of S-NEC. It was discovered that the AMC reduced more in S-NEC infants at onset, but it increased more at recovery. In addition, the authors found that among stage 1,2 and 3, stage 3 had the lowest AMC and the largest percentage decrease at the onset. Conclusion: The AMC decreases sharply in NEC infants at onset, and the degree of decline is associated with the severity of NEC. AMC is expected to be a marker of NEC and provide a reference for clinicians in the diagnosis and treatment of NEC.http://www.sciencedirect.com/science/article/pii/S0021755723000360Absolute monocyte countsNecrotizing enterocolitisPretermReduction |
| spellingShingle | Zhiru Wang Qingqi Chong Junmei Zhou Tingting Gao Kai Zhu Xiaohui Gong Qingfeng Sheng Zhibao Lv Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis Jornal de Pediatria Absolute monocyte counts Necrotizing enterocolitis Preterm Reduction |
| title | Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis |
| title_full | Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis |
| title_fullStr | Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis |
| title_full_unstemmed | Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis |
| title_short | Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis |
| title_sort | reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis |
| topic | Absolute monocyte counts Necrotizing enterocolitis Preterm Reduction |
| url | http://www.sciencedirect.com/science/article/pii/S0021755723000360 |
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