Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation
The role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-07-01
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| Series: | Frontiers in Computational Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncom.2016.00076/full |
| _version_ | 1818476510597611520 |
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| author | Yansong Chua Yansong Chua Yansong Chua Yansong Chua Abigail Morrison Abigail Morrison Abigail Morrison |
| author_facet | Yansong Chua Yansong Chua Yansong Chua Yansong Chua Abigail Morrison Abigail Morrison Abigail Morrison |
| author_sort | Yansong Chua |
| collection | DOAJ |
| description | The role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium dynamics in the distal compartment. By performing single neuron simulations with noisy synaptic input and occasional large coincident input at either just the distal compartment or at both somatic and distal compartments, we show that the presence of calcium spikes confers a substantial advantage for coincidence detection in the former case and a lesser advantage in the latter. We further show that the experimentally observed critical frequency phenomenon is not exhibited by a neuron receiving realistically noisy synaptic input, and so is unlikely to be a necessary component of coincidence detection. We next investigate the effect of calcium spikes in propagation of spiking activities in a feed-forward network embedded in a balanced recurrent network. The excitatory neurons in the network are again connected to either just the distal, or both somatic and distal compartments. With purely distal connectivity, activity propagation is stable and distinguishable for a large range of recurrent synaptic strengths if the feed-forward connections are sufficiently strong, but propagation does not occur in the absence of calcium spikes. When connections are made to both the somatic and the distal compartments, activity propagation is achieved for neurons with active calcium dynamics at a much smaller number of neurons per pool, compared to a network of passive neurons, but quickly becomes unstable as the strength of recurrent synapses increases. Activity propagation at higher scaling factors can be stabilized by increasing network inhibition or introducing short term depression in the excitatory synapses, but the signal to noise ration remains low. Our results demonstrate that the interaction of synchrony with dendritic spiking mechanisms can have profound consequences for the dynamics on the single neuron and network level. |
| first_indexed | 2024-12-10T09:26:40Z |
| format | Article |
| id | doaj.art-c36d89234ea945e2bd000d8b4e17ba17 |
| institution | Directory Open Access Journal |
| issn | 1662-5188 |
| language | English |
| last_indexed | 2024-12-10T09:26:40Z |
| publishDate | 2016-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Computational Neuroscience |
| spelling | doaj.art-c36d89234ea945e2bd000d8b4e17ba172022-12-22T01:54:30ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882016-07-011010.3389/fncom.2016.00076174649Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagationYansong Chua0Yansong Chua1Yansong Chua2Yansong Chua3Abigail Morrison4Abigail Morrison5Abigail Morrison6Albert-Ludwig University of FreiburgJülich Research CentreAlbert-Ludwig University of FreiburgInstitute for Infocomm Research, Agency for Science, Technology and Research (A*STAR)Jülich Research CentreAlbert-Ludwig University of FreiburgRuhr-University BochumThe role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium dynamics in the distal compartment. By performing single neuron simulations with noisy synaptic input and occasional large coincident input at either just the distal compartment or at both somatic and distal compartments, we show that the presence of calcium spikes confers a substantial advantage for coincidence detection in the former case and a lesser advantage in the latter. We further show that the experimentally observed critical frequency phenomenon is not exhibited by a neuron receiving realistically noisy synaptic input, and so is unlikely to be a necessary component of coincidence detection. We next investigate the effect of calcium spikes in propagation of spiking activities in a feed-forward network embedded in a balanced recurrent network. The excitatory neurons in the network are again connected to either just the distal, or both somatic and distal compartments. With purely distal connectivity, activity propagation is stable and distinguishable for a large range of recurrent synaptic strengths if the feed-forward connections are sufficiently strong, but propagation does not occur in the absence of calcium spikes. When connections are made to both the somatic and the distal compartments, activity propagation is achieved for neurons with active calcium dynamics at a much smaller number of neurons per pool, compared to a network of passive neurons, but quickly becomes unstable as the strength of recurrent synapses increases. Activity propagation at higher scaling factors can be stabilized by increasing network inhibition or introducing short term depression in the excitatory synapses, but the signal to noise ration remains low. Our results demonstrate that the interaction of synchrony with dendritic spiking mechanisms can have profound consequences for the dynamics on the single neuron and network level.http://journal.frontiersin.org/Journal/10.3389/fncom.2016.00076/fullCoincidence Detectionsynfire chainsactivity propagationcalcium spikesshort term plasticityDetailed balance |
| spellingShingle | Yansong Chua Yansong Chua Yansong Chua Yansong Chua Abigail Morrison Abigail Morrison Abigail Morrison Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation Frontiers in Computational Neuroscience Coincidence Detection synfire chains activity propagation calcium spikes short term plasticity Detailed balance |
| title | Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation |
| title_full | Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation |
| title_fullStr | Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation |
| title_full_unstemmed | Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation |
| title_short | Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation |
| title_sort | effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation |
| topic | Coincidence Detection synfire chains activity propagation calcium spikes short term plasticity Detailed balance |
| url | http://journal.frontiersin.org/Journal/10.3389/fncom.2016.00076/full |
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