A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method
We report an easy and powerful approach to the synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines derivatives by condensation of 3-Formylchromone and thiourea under conventional heating and ultrasonic irradiation. The ultrasonic irradiation is convenient and efficient method as compa...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Green and Sustainable Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666086522000248 |
| _version_ | 1811177634951856128 |
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| author | Namdeo T. Dhokale Satish B. Kale Sadashiv S. Nagre Shankaraiah G. Konda Navanath R. Dalvi |
| author_facet | Namdeo T. Dhokale Satish B. Kale Sadashiv S. Nagre Shankaraiah G. Konda Navanath R. Dalvi |
| author_sort | Namdeo T. Dhokale |
| collection | DOAJ |
| description | We report an easy and powerful approach to the synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines derivatives by condensation of 3-Formylchromone and thiourea under conventional heating and ultrasonic irradiation. The ultrasonic irradiation is convenient and efficient method as compared to conventional heating in alcoholic KOH. This method affords the desired product with good to excellent yields. The IR, 1H NMR and mass spectroscopy were obtained for selected synthesized products. |
| first_indexed | 2024-04-11T06:04:39Z |
| format | Article |
| id | doaj.art-c36f0a13b21f4f42933617dc145c2ea5 |
| institution | Directory Open Access Journal |
| issn | 2666-0865 |
| language | English |
| last_indexed | 2024-04-11T06:04:39Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Green and Sustainable Chemistry |
| spelling | doaj.art-c36f0a13b21f4f42933617dc145c2ea52022-12-22T04:41:32ZengElsevierCurrent Research in Green and Sustainable Chemistry2666-08652022-01-015100282A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional methodNamdeo T. Dhokale0Satish B. Kale1Sadashiv S. Nagre2Shankaraiah G. Konda3Navanath R. Dalvi4Department of Chemistry, K. J. Somaiya College of Arts, Commerce and Science, Savitribai Phule Pune University, Kopargaon, Ahmednagar, Maharashtra, 423601, IndiaDepartment of Chemistry, K. J. Somaiya College of Arts, Commerce and Science, Savitribai Phule Pune University, Kopargaon, Ahmednagar, Maharashtra, 423601, IndiaDepartment of Chemistry, K. J. Somaiya College of Arts, Commerce and Science, Savitribai Phule Pune University, Kopargaon, Ahmednagar, Maharashtra, 423601, IndiaDepartment of Chemistry, K. J. Somaiya College of Arts, Commerce and Science, Savitribai Phule Pune University, Kopargaon, Ahmednagar, Maharashtra, 423601, IndiaCorresponding author.; Department of Chemistry, K. J. Somaiya College of Arts, Commerce and Science, Savitribai Phule Pune University, Kopargaon, Ahmednagar, Maharashtra, 423601, IndiaWe report an easy and powerful approach to the synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines derivatives by condensation of 3-Formylchromone and thiourea under conventional heating and ultrasonic irradiation. The ultrasonic irradiation is convenient and efficient method as compared to conventional heating in alcoholic KOH. This method affords the desired product with good to excellent yields. The IR, 1H NMR and mass spectroscopy were obtained for selected synthesized products.http://www.sciencedirect.com/science/article/pii/S2666086522000248SynthesisEfficientUltrasonic irradiation3-FormylchromoneConventional heating |
| spellingShingle | Namdeo T. Dhokale Satish B. Kale Sadashiv S. Nagre Shankaraiah G. Konda Navanath R. Dalvi A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method Current Research in Green and Sustainable Chemistry Synthesis Efficient Ultrasonic irradiation 3-Formylchromone Conventional heating |
| title | A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method |
| title_full | A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method |
| title_fullStr | A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method |
| title_full_unstemmed | A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method |
| title_short | A convenient and efficient synthesis of 2-thio-5-hydroxy-5H-[1]benzopyrano[4,3-d] pyrimidines via ultrasonic irradiation compared with conventional method |
| title_sort | convenient and efficient synthesis of 2 thio 5 hydroxy 5h 1 benzopyrano 4 3 d pyrimidines via ultrasonic irradiation compared with conventional method |
| topic | Synthesis Efficient Ultrasonic irradiation 3-Formylchromone Conventional heating |
| url | http://www.sciencedirect.com/science/article/pii/S2666086522000248 |
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