Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity
The intravenous lipid emulsion (ILE) therapy is known to alleviate clinical symptoms in cases of bupivacaine-induced cardiac toxicity. However, there is insufficient information regarding histopathological damage. This study aimed to investigate whether the use of ILE therapy in rats with experiment...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2023-10-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=3038 |
| _version_ | 1827594947006562304 |
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| author | Nezir YILMAZ Mevlüt DOĞUKAN Ahmet TÜRK Fadime TOSUN |
| author_facet | Nezir YILMAZ Mevlüt DOĞUKAN Ahmet TÜRK Fadime TOSUN |
| author_sort | Nezir YILMAZ |
| collection | DOAJ |
| description | The intravenous lipid emulsion (ILE) therapy is known to alleviate clinical symptoms in
cases of bupivacaine-induced cardiac toxicity. However, there is insufficient information
regarding histopathological damage. This study aimed to investigate whether the use
of ILE therapy in rats with experimentally induced bupivacaine-related cardiac toxicity
can ameliorate histopathological damage. 28 Wistar albino rats were divided into four
groups: control (A), lipid (B), bupivacaine (C), and bupivacaine + lipid (D). After
providing monitoring in all groups, group B received 1.5 mL ILE + 0.25 μg/kg/min ILE
infusion, group C received 3 μg/kg/min bupivacaine infusion, and group D received 3
μg/kg/min bupivacaine infusion followed by 1.5 mL ILE + 0.25 μg/kg/min ILE infusion
after observing cardiac toxicity. Heart rate and respiratory rate were recorded. Blood
samples were collected post-procedure to measure LDH, CK-MB, and troponin levels.
Cardiac tissue samples were obtained for histopathological examination. There was
no significant difference in baseline heart rate and respiratory rate among the groups
(P>0.05). However, in the second measurements, heart rate and respiratory rate were
higher in group D compared to group C (P<0.05). LDH and CK-MB levels were higher
in group C compared to the other groups (P<0.05). Irisin and asprosin scores were
higher in group D compared to the other groups (P<0.05). ILE was found to have a
cardioprotective effect in the treatment of bupivacaine-induced cardiac toxicity, as it
improved both clinical and laboratory parameters. However, histologically, cardiac
damage persisted. |
| first_indexed | 2024-03-09T02:44:37Z |
| format | Article |
| id | doaj.art-c36f884a8bfa42aa834857541416bf64 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-09T02:44:37Z |
| publishDate | 2023-10-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-c36f884a8bfa42aa834857541416bf642023-12-05T21:27:26ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512023-10-0129668368810.9775/kvfd.2023.301773038Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicityNezir YILMAZ0Mevlüt DOĞUKAN1Ahmet TÜRK2Fadime TOSUN3AdıyamanUniversity, Faculty of Medicine, Anesthesiology and Reanimation Department, TR-02100 Adıyaman - TÜRKİYEAdıyamanUniversity, Faculty of Medicine, Anesthesiology and Reanimation Department, TR-02100 Adıyaman - TÜRKİYEAdıyamanUniversity, Faculty of Medicine, Histology and Embryology Department, TR-02100 Adıyaman - TÜRKİYEAdıyamanUniversity, Faculty of Medicine, Anesthesiology and Reanimation Department, TR-02100 Adıyaman - TÜRKİYEThe intravenous lipid emulsion (ILE) therapy is known to alleviate clinical symptoms in cases of bupivacaine-induced cardiac toxicity. However, there is insufficient information regarding histopathological damage. This study aimed to investigate whether the use of ILE therapy in rats with experimentally induced bupivacaine-related cardiac toxicity can ameliorate histopathological damage. 28 Wistar albino rats were divided into four groups: control (A), lipid (B), bupivacaine (C), and bupivacaine + lipid (D). After providing monitoring in all groups, group B received 1.5 mL ILE + 0.25 μg/kg/min ILE infusion, group C received 3 μg/kg/min bupivacaine infusion, and group D received 3 μg/kg/min bupivacaine infusion followed by 1.5 mL ILE + 0.25 μg/kg/min ILE infusion after observing cardiac toxicity. Heart rate and respiratory rate were recorded. Blood samples were collected post-procedure to measure LDH, CK-MB, and troponin levels. Cardiac tissue samples were obtained for histopathological examination. There was no significant difference in baseline heart rate and respiratory rate among the groups (P>0.05). However, in the second measurements, heart rate and respiratory rate were higher in group D compared to group C (P<0.05). LDH and CK-MB levels were higher in group C compared to the other groups (P<0.05). Irisin and asprosin scores were higher in group D compared to the other groups (P<0.05). ILE was found to have a cardioprotective effect in the treatment of bupivacaine-induced cardiac toxicity, as it improved both clinical and laboratory parameters. However, histologically, cardiac damage persisted.https://vetdergikafkas.org/pdf.php?id=3038bupivacainecardiac toxicityhistopathologylipid emulsion |
| spellingShingle | Nezir YILMAZ Mevlüt DOĞUKAN Ahmet TÜRK Fadime TOSUN Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity Kafkas Universitesi Veteriner Fakültesi Dergisi bupivacaine cardiac toxicity histopathology lipid emulsion |
| title | Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity |
| title_full | Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity |
| title_fullStr | Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity |
| title_full_unstemmed | Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity |
| title_short | Cardioprotective effect of intravenous lipid emulsion in bupivacaine- induced experimental cardiac toxicity |
| title_sort | cardioprotective effect of intravenous lipid emulsion in bupivacaine induced experimental cardiac toxicity |
| topic | bupivacaine cardiac toxicity histopathology lipid emulsion |
| url | https://vetdergikafkas.org/pdf.php?id=3038 |
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