Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report

Ashwin Kodliwadmath Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India Abstract: Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and pheny...

全面介绍

书目详细资料
主要作者: Kodliwadmath A
格式: 文件
语言:English
出版: Dove Medical Press 2017-07-01
丛编:International Medical Case Reports Journal
主题:
在线阅读:https://www.dovepress.com/phenytoin-induced-stevens-johnson-syndrome-with-myocarditis-a-rare-cas-peer-reviewed-article-IMCRJ
实物特征
总结:Ashwin Kodliwadmath Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India Abstract: Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the epidermis. It is commonly drug induced and phenytoin is a common precipitant. Phenytoin, an antiepileptic drug, is also known to cause myocarditis. Phenytoin causing both myocarditis and SJS in the same patient is very rare and can lead to increased morbidity and mortality. Here, we describe the case of a 43-year-old male who developed SJS and myocarditis secondary to phenytoin. In spite of aggressive resuscitative efforts, the patient could not be revived. Thus, a combination of myocarditis with SJS increases the mortality and should be considered in patients with SJS secondary to phenytoin and associated shock. Keywords: phenytoin, myocarditis, Stevens–Johnson syndrome
ISSN:1179-142X