Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations
Perinatal asphyxia is one of the leading causes of morbidity and mortality in the neonatal period. There is an on-going debate in the literature concerning the correct oxygen concentration to be used during neonatal resuscitation. Aim of this study was to investigate whether different metabolic prof...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2013-10-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/114 |
| _version_ | 1818511128516362240 |
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| author | Federica Murgia Antonio Noto Nicoletta Iacovidou Theodoros Xanthos Milena Lussu Luigi Atzori Luigi Barberini Gabriele Finco Ernesto D’Aloja Vassilios Fanos |
| author_facet | Federica Murgia Antonio Noto Nicoletta Iacovidou Theodoros Xanthos Milena Lussu Luigi Atzori Luigi Barberini Gabriele Finco Ernesto D’Aloja Vassilios Fanos |
| author_sort | Federica Murgia |
| collection | DOAJ |
| description | Perinatal asphyxia is one of the leading causes of morbidity and mortality in the neonatal period. There is an on-going debate in the literature concerning the correct oxygen concentration to be used during neonatal resuscitation. Aim of this study was to investigate whether different metabolic profiles occurred according to oxygen concentration administered and quickness of resuscitation. We tested the hypothesis that the metabolic profile may be affected by the response to the different oxygen concentration and influenced the different time of recovery. Forty male Landrace/Large newborn piglets were the subjects of the present study. As a consequence of the different time of resuscitation, a metabolomics analysis between the two classes of reoxygenated piglets with the slowest and fastest recovery was carried out: first group (4 piglets) RT < 15 minutes and second group (6 piglets) RT > 68 minutes. In addition, 1H-NMR metabolomics study was performed showing different metabolic profiles between the two groups. The most significant metabolites were: N-phenylacetylglycine, acetoacetate, methanol, glucose, sarcosine, succinate, dimethylamine and alanine. Our results seem to indicate that the rapidity of resuscitation is influenced by the oxygen concentration.
Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy) · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge research |
| first_indexed | 2024-12-10T23:29:16Z |
| format | Article |
| id | doaj.art-c3719bd1cd9e4603875661e98b8b33bf |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-10T23:29:16Z |
| publishDate | 2013-10-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-c3719bd1cd9e4603875661e98b8b33bf2022-12-22T01:29:28ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922013-10-0122e020233e02023310.7363/02023385Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrationsFederica Murgia0Antonio Noto1Nicoletta Iacovidou2Theodoros Xanthos3Milena Lussu4Luigi Atzori5Luigi Barberini6Gabriele Finco7Ernesto D’Aloja8Vassilios Fanos9Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyNeonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliero Universitaria and University of Cagliari, Cagliari, Italy2nd Department of Obstetrics and Gynecology, Neonatal Division, National and Kapodistrian, University of Athens, Medical School, GreeceNational and Kapodistrian University of Athens, Medical School, MSc “Cardiopulmonary Resuscitation”, Athens, GreeceDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyDepartment of Neurological Sciences, University of Cagliari, ItalyDepartment of Anesthesiology, University of Cagliari, ItalyForensic Science Departement, University of Cagliari, ItalyNeonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliero Universitaria and University of Cagliari, Cagliari, ItalyPerinatal asphyxia is one of the leading causes of morbidity and mortality in the neonatal period. There is an on-going debate in the literature concerning the correct oxygen concentration to be used during neonatal resuscitation. Aim of this study was to investigate whether different metabolic profiles occurred according to oxygen concentration administered and quickness of resuscitation. We tested the hypothesis that the metabolic profile may be affected by the response to the different oxygen concentration and influenced the different time of recovery. Forty male Landrace/Large newborn piglets were the subjects of the present study. As a consequence of the different time of resuscitation, a metabolomics analysis between the two classes of reoxygenated piglets with the slowest and fastest recovery was carried out: first group (4 piglets) RT < 15 minutes and second group (6 piglets) RT > 68 minutes. In addition, 1H-NMR metabolomics study was performed showing different metabolic profiles between the two groups. The most significant metabolites were: N-phenylacetylglycine, acetoacetate, methanol, glucose, sarcosine, succinate, dimethylamine and alanine. Our results seem to indicate that the rapidity of resuscitation is influenced by the oxygen concentration. Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy) · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge researchhttps://www.jpnim.com/index.php/jpnim/article/view/114metabolomicsasphyxiaresuscitationoxygenurinenewbornpiglets |
| spellingShingle | Federica Murgia Antonio Noto Nicoletta Iacovidou Theodoros Xanthos Milena Lussu Luigi Atzori Luigi Barberini Gabriele Finco Ernesto D’Aloja Vassilios Fanos Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations Journal of Pediatric and Neonatal Individualized Medicine metabolomics asphyxia resuscitation oxygen urine newborn piglets |
| title | Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations |
| title_full | Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations |
| title_fullStr | Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations |
| title_full_unstemmed | Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations |
| title_short | Is the quickness of resuscitation after hypoxia influenced by the oxygen concentration? Metabolomics in piglets resuscitated with different oxygen concentrations |
| title_sort | is the quickness of resuscitation after hypoxia influenced by the oxygen concentration metabolomics in piglets resuscitated with different oxygen concentrations |
| topic | metabolomics asphyxia resuscitation oxygen urine newborn piglets |
| url | https://www.jpnim.com/index.php/jpnim/article/view/114 |
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