Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma

Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma

Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is an effective immunotherapy for B-cell malignancies but has failed in some solid tumors clinically. Intracerebral tumors may pose challenges that are even more significant. In order to devise a treatment strategy for patient...

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Bibliographic Details
Main Authors: Carter M. Suryadevara, Rupen Desai, Melissa L. Abel, Katherine A. Riccione, Kristen A. Batich, Steven H. Shen, Pakawat Chongsathidkiet, Patrick C. Gedeon, Aladine A. Elsamadicy, David J. Snyder, James E. Herndon, Patrick Healy, Gary E. Archer, Bryan D. Choi, Peter E. Fecci, John H. Sampson, Luis Sanchez-Perez
Format: Article
Language:English
Published: Taylor & Francis Group 2018-06-01
Series:OncoImmunology
Subjects:
glioma
glioblastoma
brain tumor
immunotherapy
lymphopenia
temozolomide
adoptive transfer
chimeric antigen receptor
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1434464

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