A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster
Due to their strict maternal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutations that are beneficial or neutral in females but harmful in males. Although a few male-harming mtDNA mutations have been identified, consistent with this ‘Mother’s Curse’, th...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/16923 |
| _version_ | 1811180637055352832 |
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| author | Maulik R Patel Ganesh K Miriyala Aimee J Littleton Heiko Yang Kien Trinh Janet M Young Scott R Kennedy Yukiko M Yamashita Leo J Pallanck Harmit S Malik |
| author_facet | Maulik R Patel Ganesh K Miriyala Aimee J Littleton Heiko Yang Kien Trinh Janet M Young Scott R Kennedy Yukiko M Yamashita Leo J Pallanck Harmit S Malik |
| author_sort | Maulik R Patel |
| collection | DOAJ |
| description | Due to their strict maternal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutations that are beneficial or neutral in females but harmful in males. Although a few male-harming mtDNA mutations have been identified, consistent with this ‘Mother’s Curse’, their effect on females has been largely unexplored. Here, we identify COIIG177S, a mtDNA hypomorph of cytochrome oxidase II, which specifically impairs male fertility due to defects in sperm development and function without impairing other male or female functions. COIIG177S represents one of the clearest examples of a ‘male-harming’ mtDNA mutation in animals and suggest that the hypomorphic mtDNA mutations like COIIG177S might specifically impair male gametogenesis. Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully rescue COIIG177S -associated sterility, consistent with previously proposed models that nuclear genomes can regulate the phenotypic manifestation of mtDNA mutations. |
| first_indexed | 2024-04-11T09:06:31Z |
| format | Article |
| id | doaj.art-c373c09fcc644fbf953de27239bb24c7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:06:31Z |
| publishDate | 2016-08-01 |
| publisher | eLife Sciences Publications Ltd |
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| series | eLife |
| spelling | doaj.art-c373c09fcc644fbf953de27239bb24c72022-12-22T04:32:37ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.16923A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogasterMaulik R Patel0Ganesh K Miriyala1Aimee J Littleton2Heiko Yang3Kien Trinh4Janet M Young5https://orcid.org/0000-0001-8220-8427Scott R Kennedy6Yukiko M Yamashita7Leo J Pallanck8Harmit S Malik9https://orcid.org/0000-0001-6005-0016Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States; Howard Hughes Medical Institute, Seattle, United States; Department of Biological Sciences, Vanderbilt University, Nashville, United StatesDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United StatesDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United StatesLife Sciences Institute, University of Michigan, Ann Arbor, United States; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, United StatesGenome Sciences, University of Washington, Seattle, United StatesDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United StatesPathology, University of Washington Medical Center, Seattle, United StatesLife Sciences Institute, University of Michigan, Ann Arbor, United States; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, United StatesGenome Sciences, University of Washington, Seattle, United StatesDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States; Howard Hughes Medical Institute, Seattle, United StatesDue to their strict maternal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutations that are beneficial or neutral in females but harmful in males. Although a few male-harming mtDNA mutations have been identified, consistent with this ‘Mother’s Curse’, their effect on females has been largely unexplored. Here, we identify COIIG177S, a mtDNA hypomorph of cytochrome oxidase II, which specifically impairs male fertility due to defects in sperm development and function without impairing other male or female functions. COIIG177S represents one of the clearest examples of a ‘male-harming’ mtDNA mutation in animals and suggest that the hypomorphic mtDNA mutations like COIIG177S might specifically impair male gametogenesis. Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully rescue COIIG177S -associated sterility, consistent with previously proposed models that nuclear genomes can regulate the phenotypic manifestation of mtDNA mutations.https://elifesciences.org/articles/16923mitochondrial DNAexperimental evolutionmale fertilitysperm developmentlifespangenetic suppressors |
| spellingShingle | Maulik R Patel Ganesh K Miriyala Aimee J Littleton Heiko Yang Kien Trinh Janet M Young Scott R Kennedy Yukiko M Yamashita Leo J Pallanck Harmit S Malik A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster eLife mitochondrial DNA experimental evolution male fertility sperm development lifespan genetic suppressors |
| title | A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster |
| title_full | A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster |
| title_fullStr | A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster |
| title_full_unstemmed | A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster |
| title_short | A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster |
| title_sort | mitochondrial dna hypomorph of cytochrome oxidase specifically impairs male fertility in drosophila melanogaster |
| topic | mitochondrial DNA experimental evolution male fertility sperm development lifespan genetic suppressors |
| url | https://elifesciences.org/articles/16923 |
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