Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients

Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients

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Main Authors: Morteza Shahshahan, Mohammad-Reza Peyman, Heshmatolah Ghanbari, Ali-Reza Peyman
Format: Article
Language:English
Published: Knowledge E 2008-12-01
Series:Journal of Ophthalmic & Vision Research
Online Access:http://www.jovr.ir/index.php/jovr/article/view/60
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author Morteza Shahshahan
Mohammad-Reza Peyman
Heshmatolah Ghanbari
Ali-Reza Peyman
author_facet Morteza Shahshahan
Mohammad-Reza Peyman
Heshmatolah Ghanbari
Ali-Reza Peyman
author_sort Morteza Shahshahan
collection DOAJ
description <!--[if gte mso 9]><xml> Normal 0 false false false MicrosoftInternetExplorer4 </xml><![endif]--><!--[if gte mso 9]><xml> </xml><![endif]--> <!--[if gte mso 10]> <style>
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 </style> <![endif]--> <p>PURPOSE: To determine whether angiotensin II (AT II) levels in aqueous humor are related to diabetes mellitus and to evaluate the effect of captopril on this level. We also evaluated the correlation between severity of macular edema and captopril use. METHODS: In a case-control study, aqueous humor samples were obtained at the onset of cataract surgery from 58 eyes of 58 patients, of whom 37 were diabetic. From these latter subjects, 16 had taken captopril (captopril group) for at least six months and 21 had not taken any angiotensin converting enzyme inhibitor (non-captopril group). AT II level was assessed by radioimmunoassay. Severity of macular edema was evaluated by clinical examination after surgery. RESULTS: The aqueous level of AT II was significantly higher in diabetic patients (31.0±7.3 pg/ml) compared to non-diabetics (6.28±2.8 pg/ml) (Mann Whitney U test, P < 0.0001). In diabetic patients, aqueous concentration of AT II in the captopril group (16.3±6.5 mg/ml) was significantly lower than the non-captopril group (75.73±9.36 mg/ml) (Mann Whitney U test, P < 0.0003). The severity of macular edema was significantly less in the captopril group compared to the non-captopril group: 68.75% of the captopril group vs 33.3% of the non-captopril group had no macular edema (P < 0.005). CONCLUSION: These findings suggest that the aqueous level of AT II is higher in diabetic eyes and is correlated with the severity of diabetic macular edema. Considering the possible role of AT II in the pathogenesis of diabetic macular edema, modulation of the ocular renin-angiotensin system may become an important target for its treatment.</p> <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif]--> <!-- /* Font Definitions */ @font-face {font-family:Palatino; mso-font-alt:"Book Antiqua"; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:7 0 0 0 147 0;} @font-face {font-family:Nazanin; mso-font-alt:"Courier New"; mso-font-charset:178; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:24577 0 0 0 64 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; mso-bidi-font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:Nazanin;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <style>
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spelling doaj.art-c373e33e6569428c9c08a0766dbebc8b2022-12-22T04:38:33ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2008-12-0112106109Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic PatientsMorteza ShahshahanMohammad-Reza PeymanHeshmatolah GhanbariAli-Reza Peyman<!--[if gte mso 9]><xml> Normal 0 false false false MicrosoftInternetExplorer4 </xml><![endif]--><!--[if gte mso 9]><xml> </xml><![endif]--> <!--[if gte mso 10]> <style>
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 </style> <![endif]--> <p>PURPOSE: To determine whether angiotensin II (AT II) levels in aqueous humor are related to diabetes mellitus and to evaluate the effect of captopril on this level. We also evaluated the correlation between severity of macular edema and captopril use. METHODS: In a case-control study, aqueous humor samples were obtained at the onset of cataract surgery from 58 eyes of 58 patients, of whom 37 were diabetic. From these latter subjects, 16 had taken captopril (captopril group) for at least six months and 21 had not taken any angiotensin converting enzyme inhibitor (non-captopril group). AT II level was assessed by radioimmunoassay. Severity of macular edema was evaluated by clinical examination after surgery. RESULTS: The aqueous level of AT II was significantly higher in diabetic patients (31.0±7.3 pg/ml) compared to non-diabetics (6.28±2.8 pg/ml) (Mann Whitney U test, P < 0.0001). In diabetic patients, aqueous concentration of AT II in the captopril group (16.3±6.5 mg/ml) was significantly lower than the non-captopril group (75.73±9.36 mg/ml) (Mann Whitney U test, P < 0.0003). The severity of macular edema was significantly less in the captopril group compared to the non-captopril group: 68.75% of the captopril group vs 33.3% of the non-captopril group had no macular edema (P < 0.005). CONCLUSION: These findings suggest that the aqueous level of AT II is higher in diabetic eyes and is correlated with the severity of diabetic macular edema. Considering the possible role of AT II in the pathogenesis of diabetic macular edema, modulation of the ocular renin-angiotensin system may become an important target for its treatment.</p> <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif]--> <!-- /* Font Definitions */ @font-face {font-family:Palatino; mso-font-alt:"Book Antiqua"; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:7 0 0 0 147 0;} @font-face {font-family:Nazanin; mso-font-alt:"Courier New"; mso-font-charset:178; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:24577 0 0 0 64 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; mso-bidi-font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:Nazanin;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <style>
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spellingShingle Morteza Shahshahan
Mohammad-Reza Peyman
Heshmatolah Ghanbari
Ali-Reza Peyman
Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients
Journal of Ophthalmic & Vision Research
title Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients
title_full Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients
title_fullStr Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients
title_full_unstemmed Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients
title_short Effect of Captopril on Aqueous Levels of Angiotensin II and Its Correlation with Macular Edema in Diabetic Patients
title_sort effect of captopril on aqueous levels of angiotensin ii and its correlation with macular edema in diabetic patients
url http://www.jovr.ir/index.php/jovr/article/view/60
work_keys_str_mv AT mortezashahshahan effectofcaptoprilonaqueouslevelsofangiotensiniianditscorrelationwithmacularedemaindiabeticpatients
AT mohammadrezapeyman effectofcaptoprilonaqueouslevelsofangiotensiniianditscorrelationwithmacularedemaindiabeticpatients
AT heshmatolahghanbari effectofcaptoprilonaqueouslevelsofangiotensiniianditscorrelationwithmacularedemaindiabeticpatients
AT alirezapeyman effectofcaptoprilonaqueouslevelsofangiotensiniianditscorrelationwithmacularedemaindiabeticpatients

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