Preparation and characterization of curcumin long-circulating liposomes
In order to improve the stability of Cur-LCL and extend the circulation time of the drug in the body, the existing methods of preparing curcumin liposomes (Cur-Lips) and curcumin long-circulating liposomes (Cur-LCL) are optimized. Cur-Lips are prepared by ethanol injection method, and the Cur-LCL is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Hebei University of Science and Technology
2018-12-01
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| Series: | Journal of Hebei University of Science and Technology |
| Subjects: | |
| Online Access: | http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b201806008&flag=1&journal_ |
| _version_ | 1811265280092930048 |
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| author | Jing REN Danshen ZHANG Wenshu HOU Chunyang WU Jiacheng MA |
| author_facet | Jing REN Danshen ZHANG Wenshu HOU Chunyang WU Jiacheng MA |
| author_sort | Jing REN |
| collection | DOAJ |
| description | In order to improve the stability of Cur-LCL and extend the circulation time of the drug in the body, the existing methods of preparing curcumin liposomes (Cur-Lips) and curcumin long-circulating liposomes (Cur-LCL) are optimized. Cur-Lips are prepared by ethanol injection method, and the Cur-LCL is prepared by inserting DSPE-PEG2000 into Cur-Lips by post-insertion. The results show the appearance is a circular vesicular sphere, and the average encapsulation efficiency is (88.91±0.94)%, which stays unchanged at 4 ℃ for 15 days; the average leakage rate is 2.4%, which has good stability; the average particle size is (118.4±3.2) nm (n=3), showing a single peak distribution, and the average potential is (-12.9±0.32) mV (n=3); the dissolution medium is selected according to the solubility standard, and the physiological solution of 1% Tween 80 is selected as the dissolution medium for the in vitro release experiment. Cur APIs are almost completely released at 12 h while Cur-Lips are almost completely released at 36 h, and the cumulative release rate is 92.67%. Cur-LCL is almost completely released at 72 h, and the cumulative release rate is 91.36%. Cur-LCL has obvious function in slowing the release process, which could prolong the circulation time of the drug in the blood and achieve long-circulation effects. |
| first_indexed | 2024-04-12T20:20:53Z |
| format | Article |
| id | doaj.art-c3745b9713c64b07b175a31ea2954bb1 |
| institution | Directory Open Access Journal |
| issn | 1008-1542 |
| language | zho |
| last_indexed | 2024-04-12T20:20:53Z |
| publishDate | 2018-12-01 |
| publisher | Hebei University of Science and Technology |
| record_format | Article |
| series | Journal of Hebei University of Science and Technology |
| spelling | doaj.art-c3745b9713c64b07b175a31ea2954bb12022-12-22T03:18:00ZzhoHebei University of Science and TechnologyJournal of Hebei University of Science and Technology1008-15422018-12-0139653253910.7535/hbkd.2018yx06008b201806008Preparation and characterization of curcumin long-circulating liposomesJing REN0Danshen ZHANG1Wenshu HOU2Chunyang WU3Jiacheng MA4School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018,ChinaSchool of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018,ChinaSchool of Pharmacy, Hebei North University, Zhangjiakou, Hebei 075000,ChinaSchool of Pharmacy, Hebei North University, Zhangjiakou, Hebei 075000,ChinaSchool of Pharmacy, Hebei North University, Zhangjiakou, Hebei 075000,ChinaIn order to improve the stability of Cur-LCL and extend the circulation time of the drug in the body, the existing methods of preparing curcumin liposomes (Cur-Lips) and curcumin long-circulating liposomes (Cur-LCL) are optimized. Cur-Lips are prepared by ethanol injection method, and the Cur-LCL is prepared by inserting DSPE-PEG2000 into Cur-Lips by post-insertion. The results show the appearance is a circular vesicular sphere, and the average encapsulation efficiency is (88.91±0.94)%, which stays unchanged at 4 ℃ for 15 days; the average leakage rate is 2.4%, which has good stability; the average particle size is (118.4±3.2) nm (n=3), showing a single peak distribution, and the average potential is (-12.9±0.32) mV (n=3); the dissolution medium is selected according to the solubility standard, and the physiological solution of 1% Tween 80 is selected as the dissolution medium for the in vitro release experiment. Cur APIs are almost completely released at 12 h while Cur-Lips are almost completely released at 36 h, and the cumulative release rate is 92.67%. Cur-LCL is almost completely released at 72 h, and the cumulative release rate is 91.36%. Cur-LCL has obvious function in slowing the release process, which could prolong the circulation time of the drug in the blood and achieve long-circulation effects.http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b201806008&flag=1&journal_pharmacy of Chinese materia medicacurcumin(Cur)long circulating liposomesencapsulation ratein vitro release |
| spellingShingle | Jing REN Danshen ZHANG Wenshu HOU Chunyang WU Jiacheng MA Preparation and characterization of curcumin long-circulating liposomes Journal of Hebei University of Science and Technology pharmacy of Chinese materia medica curcumin(Cur) long circulating liposomes encapsulation rate in vitro release |
| title | Preparation and characterization of curcumin long-circulating liposomes |
| title_full | Preparation and characterization of curcumin long-circulating liposomes |
| title_fullStr | Preparation and characterization of curcumin long-circulating liposomes |
| title_full_unstemmed | Preparation and characterization of curcumin long-circulating liposomes |
| title_short | Preparation and characterization of curcumin long-circulating liposomes |
| title_sort | preparation and characterization of curcumin long circulating liposomes |
| topic | pharmacy of Chinese materia medica curcumin(Cur) long circulating liposomes encapsulation rate in vitro release |
| url | http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b201806008&flag=1&journal_ |
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