Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients
Abstract Introduction Older individuals and, in particular, individuals at risk of recurrent stroke, may be susceptible to thrombosis when participating in exercise, however, this aspect has not been well investigated. Methods Clot microstructure and conventional markers of thrombotic risk were dete...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-024-00604-9 |
| _version_ | 1797219689859907584 |
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| author | L. B. Nørregaard K. A. Wickham J. S. Jeppesen N. Rytter L. C. Christoffersen L. Gliemann M. Lawrence P. A. Evans C. Kruuse Y. Hellsten |
| author_facet | L. B. Nørregaard K. A. Wickham J. S. Jeppesen N. Rytter L. C. Christoffersen L. Gliemann M. Lawrence P. A. Evans C. Kruuse Y. Hellsten |
| author_sort | L. B. Nørregaard |
| collection | DOAJ |
| description | Abstract Introduction Older individuals and, in particular, individuals at risk of recurrent stroke, may be susceptible to thrombosis when participating in exercise, however, this aspect has not been well investigated. Methods Clot microstructure and conventional markers of thrombotic risk were determined in twenty lacunar stroke patients and fifteen healthy age-matched controls before, immediately after and 1 h after a bout of moderate intensity cycling exercise. Data were analyzed using a linear mixed model approach. Results At rest, clot microstructure (1.69 ± 0.07 vs. 1.64 ± 0.05, corresponding to a difference of ~ 50% in normalized clot mass; p = 0.009) and thrombocyte count (73%; p < 0.0001) were higher, and activated partial thromboplastin time was lower (18%; p = 0.0001) in stroke patients compared to age-matched controls. Acute exercise increased thrombogenic markers similarly in the two groups: incipient clot microstructure (1.69 ± 0.07 vs. 1.74 ± 0.05; p = 0.0004 and 1.64 ± 0.05 vs. 1.71 ± 0.04; p < 0.0001, for stroke and controls respectively), plasma fibrinogen (12%; p < 0.0001 and 18%; p < 0.0001, for stroke and controls respectively) and the combined coagulation factors II, VII and X (p = 0.0001 and p < 0.0001, for stroke and controls respectively). Conclusion The results show that exercise transiently increases the risk of blood clot formation in both stroke patients and controls, however, due to the higher baseline thrombogenicity in stroke patients, the post exercise risk of forming blood clots may be higher in this group. Trial registration Registered at ClinicalTrials.gov (NCT03635177). |
| first_indexed | 2024-04-24T12:37:39Z |
| format | Article |
| id | doaj.art-c374a2a77d3649d096a66e7f802683d8 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-24T12:37:39Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-c374a2a77d3649d096a66e7f802683d82024-04-07T11:27:37ZengBMCThrombosis Journal1477-95602024-04-0122111110.1186/s12959-024-00604-9Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patientsL. B. Nørregaard0K. A. Wickham1J. S. Jeppesen2N. Rytter3L. C. Christoffersen4L. Gliemann5M. Lawrence6P. A. Evans7C. Kruuse8Y. Hellsten9The Department of Nutrition, Exercise and Sports, University of CopenhagenThe Department of Nutrition, Exercise and Sports, University of CopenhagenThe Department of Nutrition, Exercise and Sports, University of CopenhagenThe Department of Nutrition, Exercise and Sports, University of CopenhagenThe Department of Nutrition, Exercise and Sports, University of CopenhagenThe Department of Nutrition, Exercise and Sports, University of CopenhagenWelsh Centre for Emergency Medicine Research, Morriston Hospital, Swansea Bay University Health BoardWelsh Centre for Emergency Medicine Research, Morriston Hospital, Swansea Bay University Health BoardNeurovascular Research Unit, Department of Neurology, Herlev Gentofte Hospital, University of CopenhagenThe Department of Nutrition, Exercise and Sports, University of CopenhagenAbstract Introduction Older individuals and, in particular, individuals at risk of recurrent stroke, may be susceptible to thrombosis when participating in exercise, however, this aspect has not been well investigated. Methods Clot microstructure and conventional markers of thrombotic risk were determined in twenty lacunar stroke patients and fifteen healthy age-matched controls before, immediately after and 1 h after a bout of moderate intensity cycling exercise. Data were analyzed using a linear mixed model approach. Results At rest, clot microstructure (1.69 ± 0.07 vs. 1.64 ± 0.05, corresponding to a difference of ~ 50% in normalized clot mass; p = 0.009) and thrombocyte count (73%; p < 0.0001) were higher, and activated partial thromboplastin time was lower (18%; p = 0.0001) in stroke patients compared to age-matched controls. Acute exercise increased thrombogenic markers similarly in the two groups: incipient clot microstructure (1.69 ± 0.07 vs. 1.74 ± 0.05; p = 0.0004 and 1.64 ± 0.05 vs. 1.71 ± 0.04; p < 0.0001, for stroke and controls respectively), plasma fibrinogen (12%; p < 0.0001 and 18%; p < 0.0001, for stroke and controls respectively) and the combined coagulation factors II, VII and X (p = 0.0001 and p < 0.0001, for stroke and controls respectively). Conclusion The results show that exercise transiently increases the risk of blood clot formation in both stroke patients and controls, however, due to the higher baseline thrombogenicity in stroke patients, the post exercise risk of forming blood clots may be higher in this group. Trial registration Registered at ClinicalTrials.gov (NCT03635177).https://doi.org/10.1186/s12959-024-00604-9Lacunar stroke patientsExerciseClot microstructureCoagulationThrombogenicity |
| spellingShingle | L. B. Nørregaard K. A. Wickham J. S. Jeppesen N. Rytter L. C. Christoffersen L. Gliemann M. Lawrence P. A. Evans C. Kruuse Y. Hellsten Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients Thrombosis Journal Lacunar stroke patients Exercise Clot microstructure Coagulation Thrombogenicity |
| title | Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients |
| title_full | Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients |
| title_fullStr | Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients |
| title_full_unstemmed | Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients |
| title_short | Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients |
| title_sort | exercise transiently increases the density of incipient blood clots in antiplatelet treated lacunar stroke patients |
| topic | Lacunar stroke patients Exercise Clot microstructure Coagulation Thrombogenicity |
| url | https://doi.org/10.1186/s12959-024-00604-9 |
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