STING Targeting in Lung Diseases
The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the contex...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/21/3483 |
| _version_ | 1797468738408153088 |
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| author | Dorian de Moura Rodrigues Norinne Lacerda-Queiroz Isabelle Couillin Nicolas Riteau |
| author_facet | Dorian de Moura Rodrigues Norinne Lacerda-Queiroz Isabelle Couillin Nicolas Riteau |
| author_sort | Dorian de Moura Rodrigues |
| collection | DOAJ |
| description | The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy. |
| first_indexed | 2024-03-09T19:11:41Z |
| format | Article |
| id | doaj.art-c375d078fcd7431a9e9616c8784f1332 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:41Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c375d078fcd7431a9e9616c8784f13322023-11-24T04:09:34ZengMDPI AGCells2073-44092022-11-011121348310.3390/cells11213483STING Targeting in Lung DiseasesDorian de Moura Rodrigues0Norinne Lacerda-Queiroz1Isabelle Couillin2Nicolas Riteau3Experimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, FranceKey-Obs: Preclinical CRO, 45100 Orleans, FranceExperimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, FranceExperimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, FranceThe cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy.https://www.mdpi.com/2073-4409/11/21/3483lungSTINGadjuvantvaccine |
| spellingShingle | Dorian de Moura Rodrigues Norinne Lacerda-Queiroz Isabelle Couillin Nicolas Riteau STING Targeting in Lung Diseases Cells lung STING adjuvant vaccine |
| title | STING Targeting in Lung Diseases |
| title_full | STING Targeting in Lung Diseases |
| title_fullStr | STING Targeting in Lung Diseases |
| title_full_unstemmed | STING Targeting in Lung Diseases |
| title_short | STING Targeting in Lung Diseases |
| title_sort | sting targeting in lung diseases |
| topic | lung STING adjuvant vaccine |
| url | https://www.mdpi.com/2073-4409/11/21/3483 |
| work_keys_str_mv | AT doriandemourarodrigues stingtargetinginlungdiseases AT norinnelacerdaqueiroz stingtargetinginlungdiseases AT isabellecouillin stingtargetinginlungdiseases AT nicolasriteau stingtargetinginlungdiseases |