Discovery of anti-SARS-CoV-2 secondary metabolites from the heartwood of Pterocarpus santalinus using multi-informative molecular networking

Discovery of anti-SARS-CoV-2 secondary metabolites from the heartwood of Pterocarpus santalinus using multi-informative molecular networking

A pigment-depleted extract from the heartwood of Pterocarpus santalinus L. f. (PS-DE) showed promising anti-SARS-CoV-2 activity with an IC50 of 29.9 μg/mL in Caco-2-F03 cells. To determine the potential active constituents within the extract prior to isolation, multi-informative molecular network (M...

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Bibliographic Details
Main Authors: Andreas Wasilewicz, Julia Zwirchmayr, Benjamin Kirchweger, Denisa Bojkova, Jindrich Cinatl, Holger F. Rabenau, Judith M. Rollinger, Mehdi A. Beniddir, Ulrike Grienke
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
molecular networking
Pterocarpus santalinus
sandalwood
analysis
natural product
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1202394/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1202394/full

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