Auricular erythermalgia showing excellent response to itraconazole: a case report
Erythermalgia, a rare painful disorder, is characterized by recurrent pain attacking, warmth, and erythema that mainly involves the distal extremities. Red ear syndrome shares similar clinical features of erythermalgia afflicting the external ear with unilateral/bilateral distribution. The treatment...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223221099335 |
| _version_ | 1811335700579090432 |
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| author | Yan-Ting Ye Jing-Fa Lu Hui-Hui Wu Juan-Hua Liu Yu-Kun Zhao Di-Qing Luo |
| author_facet | Yan-Ting Ye Jing-Fa Lu Hui-Hui Wu Juan-Hua Liu Yu-Kun Zhao Di-Qing Luo |
| author_sort | Yan-Ting Ye |
| collection | DOAJ |
| description | Erythermalgia, a rare painful disorder, is characterized by recurrent pain attacking, warmth, and erythema that mainly involves the distal extremities. Red ear syndrome shares similar clinical features of erythermalgia afflicting the external ear with unilateral/bilateral distribution. The treatments of both diseases are still difficult without controlled therapeutics available up to date. A 12-year-old boy was referred because of 3 years of recurrent attacking of painful erythema and warmth that involved the ears alone, the episodes occurred several times daily with duration of dozens of minutes to hours for each flare. The symptoms could be relieved by cold water and triggered by heat stimuli as well as exciting and movement, and showed mild response to gabapentin, celecoxib, and topical lidocaine compounds in combination, but moderate to blocking injection of botulinum toxin to nervus auricularis magnus. However, systemic itraconazole 200 mg daily resulted in an excellent response after 5-week treatment, leading to milder erythema, warmth and burning sensation, shorter duration, and fewer relapses. The treatment continued for 6 months and then itraconazole was decreased to 100 mg daily for another 6 months until it was stopped, with maintenance of good conditions. In 3 months of follow-up after the treatment ceased, the patient had only 7 to 8 attacks over 10 days presenting as tolerable erythema that lasted for less than 10 min and relieved spontaneously, with absence of warmth and no need of treatment. We considered the patient to be a variant of erythermalgia rather than a red ear syndrome. The results showed that erythermalgia might involve the ears alone and itraconazole might be a potential agent for its treatment. |
| first_indexed | 2024-04-13T17:29:05Z |
| format | Article |
| id | doaj.art-c379d43b819a47e1ba613b6e2246a316 |
| institution | Directory Open Access Journal |
| issn | 2040-6231 |
| language | English |
| last_indexed | 2024-04-13T17:29:05Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj.art-c379d43b819a47e1ba613b6e2246a3162022-12-22T02:37:40ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312022-05-011310.1177/20406223221099335Auricular erythermalgia showing excellent response to itraconazole: a case reportYan-Ting YeJing-Fa LuHui-Hui WuJuan-Hua LiuYu-Kun ZhaoDi-Qing LuoErythermalgia, a rare painful disorder, is characterized by recurrent pain attacking, warmth, and erythema that mainly involves the distal extremities. Red ear syndrome shares similar clinical features of erythermalgia afflicting the external ear with unilateral/bilateral distribution. The treatments of both diseases are still difficult without controlled therapeutics available up to date. A 12-year-old boy was referred because of 3 years of recurrent attacking of painful erythema and warmth that involved the ears alone, the episodes occurred several times daily with duration of dozens of minutes to hours for each flare. The symptoms could be relieved by cold water and triggered by heat stimuli as well as exciting and movement, and showed mild response to gabapentin, celecoxib, and topical lidocaine compounds in combination, but moderate to blocking injection of botulinum toxin to nervus auricularis magnus. However, systemic itraconazole 200 mg daily resulted in an excellent response after 5-week treatment, leading to milder erythema, warmth and burning sensation, shorter duration, and fewer relapses. The treatment continued for 6 months and then itraconazole was decreased to 100 mg daily for another 6 months until it was stopped, with maintenance of good conditions. In 3 months of follow-up after the treatment ceased, the patient had only 7 to 8 attacks over 10 days presenting as tolerable erythema that lasted for less than 10 min and relieved spontaneously, with absence of warmth and no need of treatment. We considered the patient to be a variant of erythermalgia rather than a red ear syndrome. The results showed that erythermalgia might involve the ears alone and itraconazole might be a potential agent for its treatment.https://doi.org/10.1177/20406223221099335 |
| spellingShingle | Yan-Ting Ye Jing-Fa Lu Hui-Hui Wu Juan-Hua Liu Yu-Kun Zhao Di-Qing Luo Auricular erythermalgia showing excellent response to itraconazole: a case report Therapeutic Advances in Chronic Disease |
| title | Auricular erythermalgia showing excellent response to itraconazole: a case report |
| title_full | Auricular erythermalgia showing excellent response to itraconazole: a case report |
| title_fullStr | Auricular erythermalgia showing excellent response to itraconazole: a case report |
| title_full_unstemmed | Auricular erythermalgia showing excellent response to itraconazole: a case report |
| title_short | Auricular erythermalgia showing excellent response to itraconazole: a case report |
| title_sort | auricular erythermalgia showing excellent response to itraconazole a case report |
| url | https://doi.org/10.1177/20406223221099335 |
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