Roles of immune dysregulation in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Its occurrence and progression involve the process from simple hepatic steatosis to metabolic dysfunction associated steatohepatitis (MASH), which could develop into advanced liver fi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301867X |
| _version_ | 1797364251296268288 |
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| author | Tingyu Dong Jiajin Li Yuqing Liu Shikai Zhou Xiang Wei Hongting Hua Kechao Tang Xiaomin Zhang Yiming Wang Zhen Wu Chaobing Gao Huabing Zhang |
| author_facet | Tingyu Dong Jiajin Li Yuqing Liu Shikai Zhou Xiang Wei Hongting Hua Kechao Tang Xiaomin Zhang Yiming Wang Zhen Wu Chaobing Gao Huabing Zhang |
| author_sort | Tingyu Dong |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Its occurrence and progression involve the process from simple hepatic steatosis to metabolic dysfunction associated steatohepatitis (MASH), which could develop into advanced liver fibrosis, cirrhosis, or hepatocellular carcinoma (HCC). Growing evidences support that the pathogenesis and progression of MASLD are closely related to immune system dysfunction. This review aims to summarize the association of MASLD with immune disorders and the prospect of using immunotherapy for MASLD. |
| first_indexed | 2024-03-08T16:33:36Z |
| format | Article |
| id | doaj.art-c379d5516ddc4939a7d3e913fca03b01 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:36Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-c379d5516ddc4939a7d3e913fca03b012024-01-06T04:38:10ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170116069Roles of immune dysregulation in MASLDTingyu Dong0Jiajin Li1Yuqing Liu2Shikai Zhou3Xiang Wei4Hongting Hua5Kechao Tang6Xiaomin Zhang7Yiming Wang8Zhen Wu9Chaobing Gao10Huabing Zhang11The Second Clinical Medical College of Anhui Medical University, Hefei 230032, China; Department of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaThe Second Clinical Medical College of Anhui Medical University, Hefei 230032, China; Department of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaThe Second Clinical Medical College of Anhui Medical University, Hefei 230032, ChinaDepartment of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China; Corresponding authors.Department of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, China; Corresponding authors.Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Its occurrence and progression involve the process from simple hepatic steatosis to metabolic dysfunction associated steatohepatitis (MASH), which could develop into advanced liver fibrosis, cirrhosis, or hepatocellular carcinoma (HCC). Growing evidences support that the pathogenesis and progression of MASLD are closely related to immune system dysfunction. This review aims to summarize the association of MASLD with immune disorders and the prospect of using immunotherapy for MASLD.http://www.sciencedirect.com/science/article/pii/S075333222301867XMASLDImmune dysregulationMetabolic disordersLipid metabolism |
| spellingShingle | Tingyu Dong Jiajin Li Yuqing Liu Shikai Zhou Xiang Wei Hongting Hua Kechao Tang Xiaomin Zhang Yiming Wang Zhen Wu Chaobing Gao Huabing Zhang Roles of immune dysregulation in MASLD Biomedicine & Pharmacotherapy MASLD Immune dysregulation Metabolic disorders Lipid metabolism |
| title | Roles of immune dysregulation in MASLD |
| title_full | Roles of immune dysregulation in MASLD |
| title_fullStr | Roles of immune dysregulation in MASLD |
| title_full_unstemmed | Roles of immune dysregulation in MASLD |
| title_short | Roles of immune dysregulation in MASLD |
| title_sort | roles of immune dysregulation in masld |
| topic | MASLD Immune dysregulation Metabolic disorders Lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S075333222301867X |
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