Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens

Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens

Poly(ADP-ribose) (PAR) is a molecular scaffold that aids in the formation of DNA repair protein complexes. Tools to sensitively quantify PAR in live cells have been lacking. We recently described the LivePAR probe (EGFP fused to the RNF146-encoded WWE PAR binding domain) to measure PAR formation at...

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Bibliographic Details
Main Authors: Christopher A. Koczor, Aaron J. Haider, Kate M. Saville, Jianfeng Li, Joel F. Andrews, Alison V. Beiser, Robert W. Sobol
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
Poly(ADP-ribose)
PAR
LivePAR
WWE
split luciferase
BER
Online Access:https://www.mdpi.com/2072-6694/14/15/3676

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