HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

Abstract Background Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activ...

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Bibliographic Details
Main Authors: Giovanni Sarnelli, Luisa Seguella, Marcella Pesce, Jie Lu, Stefano Gigli, Eugenia Bruzzese, Roberta Lattanzi, Alessandra D’Alessandro, Rosario Cuomo, Luca Steardo, Giuseppe Esposito
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
HIV-1 Tat protein
EGCs
Diarrhea
Neuroinflammation
PEA
Online Access:http://link.springer.com/article/10.1186/s12974-018-1126-4

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