The epithelial-to-mesenchymal transition in cancer: pathogenetic features
The epithelial‑to‑mesenchymal transition (EMT) is a cellular biological process, that occurs in a wide range of cells and tissues and is triggered by complex regulatory networks involving transcriptional control with SNAIL, ZEB1, ZEB2, Twist, SLUG, E‑cadherin, vimentin, tumor microenvironment and ge...
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| Format: | Article |
| Language: | Russian |
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Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1
2022-06-01
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| Series: | Инновационная медицина Кубани |
| Subjects: | |
| Online Access: | https://www.innovmedkub.ru/jour/article/view/543 |
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| author | E. A. Pasechnikova V. N. Bodnya D. V. Kadomtsev A. Yu. Georgieva V. A. Porhanov D. D. Shevchuk |
| author_facet | E. A. Pasechnikova V. N. Bodnya D. V. Kadomtsev A. Yu. Georgieva V. A. Porhanov D. D. Shevchuk |
| author_sort | E. A. Pasechnikova |
| collection | DOAJ |
| description | The epithelial‑to‑mesenchymal transition (EMT) is a cellular biological process, that occurs in a wide range of cells and tissues and is triggered by complex regulatory networks involving transcriptional control with SNAIL, ZEB1, ZEB2, Twist, SLUG, E‑cadherin, vimentin, tumor microenvironment and genetic characteristics. EMT is represented by the multi‑stage development and transformation of cells of the epithelial phenotype into cells that acquire mesenchymal features of various severity. These quasi‑mesenchymal cells are characterized by stemness, tumor heterogeneity, increasing invasiveness, drug resistance and a tendency to distant metastasis, which leads to the proliferation of neoplastic cells, tumor dissemination and initiation of metastasis, which induces the therapy resistance and the oncological recurrence.This review is based on the latest scientific publications about the EMT phenomenon, indexed in PubMed. The aim of the study was to evaluate the biochemical and molecular pathogenetic mechanisms of EMT and the effect of EMT markers on the progression of neoplastic processes and the effectiveness of the treatment. Nowadays the proper EMT scheme that combines all the molecular transformations of sells with quasi‑mesenchymal phenotype doesn’t exist. But analyzing the features of this cellular program, we can find the proper therapy, that could be able to suppress the plasticity of cancer cells, prevent EMT induction by blocking contextual signals, and induce mesenchymal‑epithelial transition. All these aspects will lead to the reduction of the risk of tumor dissemination and the increase of the effectiveness of cancer treatment. |
| first_indexed | 2024-03-07T15:36:02Z |
| format | Article |
| id | doaj.art-c37fe52ab7334f158aeb7ff5266aa4c2 |
| institution | Directory Open Access Journal |
| issn | 2541-9897 |
| language | Russian |
| last_indexed | 2024-03-07T15:36:02Z |
| publishDate | 2022-06-01 |
| publisher | Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1 |
| record_format | Article |
| series | Инновационная медицина Кубани |
| spelling | doaj.art-c37fe52ab7334f158aeb7ff5266aa4c22024-03-05T11:12:31ZrusScientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1Инновационная медицина Кубани2541-98972022-06-0102859210.35401/2541-9897-2022-25-2-85-92332The epithelial-to-mesenchymal transition in cancer: pathogenetic featuresE. A. Pasechnikova0V. N. Bodnya1D. V. Kadomtsev2A. Yu. Georgieva3V. A. Porhanov4D. D. Shevchuk5Kuban State Medical UniversityKuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1Clinical Oncology Dispensary no. 1Kuban State Medical UniversityKuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital no. 1Kuban State Medical UniversityThe epithelial‑to‑mesenchymal transition (EMT) is a cellular biological process, that occurs in a wide range of cells and tissues and is triggered by complex regulatory networks involving transcriptional control with SNAIL, ZEB1, ZEB2, Twist, SLUG, E‑cadherin, vimentin, tumor microenvironment and genetic characteristics. EMT is represented by the multi‑stage development and transformation of cells of the epithelial phenotype into cells that acquire mesenchymal features of various severity. These quasi‑mesenchymal cells are characterized by stemness, tumor heterogeneity, increasing invasiveness, drug resistance and a tendency to distant metastasis, which leads to the proliferation of neoplastic cells, tumor dissemination and initiation of metastasis, which induces the therapy resistance and the oncological recurrence.This review is based on the latest scientific publications about the EMT phenomenon, indexed in PubMed. The aim of the study was to evaluate the biochemical and molecular pathogenetic mechanisms of EMT and the effect of EMT markers on the progression of neoplastic processes and the effectiveness of the treatment. Nowadays the proper EMT scheme that combines all the molecular transformations of sells with quasi‑mesenchymal phenotype doesn’t exist. But analyzing the features of this cellular program, we can find the proper therapy, that could be able to suppress the plasticity of cancer cells, prevent EMT induction by blocking contextual signals, and induce mesenchymal‑epithelial transition. All these aspects will lead to the reduction of the risk of tumor dissemination and the increase of the effectiveness of cancer treatment.https://www.innovmedkub.ru/jour/article/view/543epithelial‑to‑mesenchymal transitiontumor microenvironmentstemnesstumor heterogeneitycancer stem cell |
| spellingShingle | E. A. Pasechnikova V. N. Bodnya D. V. Kadomtsev A. Yu. Georgieva V. A. Porhanov D. D. Shevchuk The epithelial-to-mesenchymal transition in cancer: pathogenetic features Инновационная медицина Кубани epithelial‑to‑mesenchymal transition tumor microenvironment stemness tumor heterogeneity cancer stem cell |
| title | The epithelial-to-mesenchymal transition in cancer: pathogenetic features |
| title_full | The epithelial-to-mesenchymal transition in cancer: pathogenetic features |
| title_fullStr | The epithelial-to-mesenchymal transition in cancer: pathogenetic features |
| title_full_unstemmed | The epithelial-to-mesenchymal transition in cancer: pathogenetic features |
| title_short | The epithelial-to-mesenchymal transition in cancer: pathogenetic features |
| title_sort | epithelial to mesenchymal transition in cancer pathogenetic features |
| topic | epithelial‑to‑mesenchymal transition tumor microenvironment stemness tumor heterogeneity cancer stem cell |
| url | https://www.innovmedkub.ru/jour/article/view/543 |
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