Ultrasound and nanomaterial: an efficient pair to fight cancer
Abstract Ultrasounds are often used in cancer treatment protocols, e.g. to collect tumor tissues in the right location using ultrasound-guided biopsy, to image the region of the tumor using more affordable and easier to use apparatus than MRI and CT, or to ablate tumor tissues using HIFU. The effica...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-03-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01243-w |
| _version_ | 1797999289223348224 |
|---|---|
| author | Edouard Alphandéry |
| author_facet | Edouard Alphandéry |
| author_sort | Edouard Alphandéry |
| collection | DOAJ |
| description | Abstract Ultrasounds are often used in cancer treatment protocols, e.g. to collect tumor tissues in the right location using ultrasound-guided biopsy, to image the region of the tumor using more affordable and easier to use apparatus than MRI and CT, or to ablate tumor tissues using HIFU. The efficacy of these methods can be further improved by combining them with various nano-systems, thus enabling: (i) a better resolution of ultrasound imaging, allowing for example the visualization of angiogenic blood vessels, (ii) the specific tumor targeting of anti-tumor chemotherapeutic drugs or gases attached to or encapsulated in nano-systems and released in a controlled manner in the tumor under ultrasound application, (iii) tumor treatment at tumor site using more moderate heating temperatures than with HIFU. Furthermore, some nano-systems display adjustable sizes, i.e. nanobubbles can grow into micro-bubbles. Such dual size is advantageous since it enables gathering within the same unit the targeting properties of nano bubbles via EPR effect and the enhanced ultrasound contrasting properties of micro bubbles. Interestingly, the way in which nano-systems act against a tumor could in principle also be adjusted by accurately selecting the nano-system among a large choice and by tuning the values of the ultrasound parameters, which can lead, due to their mechanical nature, to specific effects such as cavitation that are usually not observed with purely electromagnetic waves and can potentially help destroying the tumor. This review highlights the clinical potential of these combined treatments that can improve the benefit/risk ratio of current cancer treatments. Graphical Abstract |
| first_indexed | 2024-04-11T11:02:17Z |
| format | Article |
| id | doaj.art-c37fe6f5a4eb41f78b1450250e4d5ca6 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T11:02:17Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-c37fe6f5a4eb41f78b1450250e4d5ca62022-12-22T04:28:34ZengBMCJournal of Nanobiotechnology1477-31552022-03-0120113010.1186/s12951-022-01243-wUltrasound and nanomaterial: an efficient pair to fight cancerEdouard Alphandéry0Sorbonne Université, Muséum National d’Histoire Naturelle, UMR CNRS, 7590, IRD, Institut de Minéralogie, de Physique des Matériaux et de. Cosmochimie, IMPMCAbstract Ultrasounds are often used in cancer treatment protocols, e.g. to collect tumor tissues in the right location using ultrasound-guided biopsy, to image the region of the tumor using more affordable and easier to use apparatus than MRI and CT, or to ablate tumor tissues using HIFU. The efficacy of these methods can be further improved by combining them with various nano-systems, thus enabling: (i) a better resolution of ultrasound imaging, allowing for example the visualization of angiogenic blood vessels, (ii) the specific tumor targeting of anti-tumor chemotherapeutic drugs or gases attached to or encapsulated in nano-systems and released in a controlled manner in the tumor under ultrasound application, (iii) tumor treatment at tumor site using more moderate heating temperatures than with HIFU. Furthermore, some nano-systems display adjustable sizes, i.e. nanobubbles can grow into micro-bubbles. Such dual size is advantageous since it enables gathering within the same unit the targeting properties of nano bubbles via EPR effect and the enhanced ultrasound contrasting properties of micro bubbles. Interestingly, the way in which nano-systems act against a tumor could in principle also be adjusted by accurately selecting the nano-system among a large choice and by tuning the values of the ultrasound parameters, which can lead, due to their mechanical nature, to specific effects such as cavitation that are usually not observed with purely electromagnetic waves and can potentially help destroying the tumor. This review highlights the clinical potential of these combined treatments that can improve the benefit/risk ratio of current cancer treatments. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01243-wNanomaterialsNanotechnologyNanomedicineNano-oncologyCancerUltrasound |
| spellingShingle | Edouard Alphandéry Ultrasound and nanomaterial: an efficient pair to fight cancer Journal of Nanobiotechnology Nanomaterials Nanotechnology Nanomedicine Nano-oncology Cancer Ultrasound |
| title | Ultrasound and nanomaterial: an efficient pair to fight cancer |
| title_full | Ultrasound and nanomaterial: an efficient pair to fight cancer |
| title_fullStr | Ultrasound and nanomaterial: an efficient pair to fight cancer |
| title_full_unstemmed | Ultrasound and nanomaterial: an efficient pair to fight cancer |
| title_short | Ultrasound and nanomaterial: an efficient pair to fight cancer |
| title_sort | ultrasound and nanomaterial an efficient pair to fight cancer |
| topic | Nanomaterials Nanotechnology Nanomedicine Nano-oncology Cancer Ultrasound |
| url | https://doi.org/10.1186/s12951-022-01243-w |
| work_keys_str_mv | AT edouardalphandery ultrasoundandnanomaterialanefficientpairtofightcancer |