Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey
Since no pharmaceuticals have been proven to effectively reduce liver fibrosis, dietary fatty acids may be beneficial as one of the non-pharmaceutical interventions due to their important roles in liver metabolism. In this cross-sectional study, we analyzed the data from the 2017–2018 cycle of Natio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.938645/full |
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| author | Tingting Zhu Tingting Zhu Tingting Zhu Tingting Zhu Xiao-Ting Lu Xiao-Ting Lu Zhao-Yan Liu Zhao-Yan Liu Hui-Lian Zhu Hui-Lian Zhu |
| author_facet | Tingting Zhu Tingting Zhu Tingting Zhu Tingting Zhu Xiao-Ting Lu Xiao-Ting Lu Zhao-Yan Liu Zhao-Yan Liu Hui-Lian Zhu Hui-Lian Zhu |
| author_sort | Tingting Zhu |
| collection | DOAJ |
| description | Since no pharmaceuticals have been proven to effectively reduce liver fibrosis, dietary fatty acids may be beneficial as one of the non-pharmaceutical interventions due to their important roles in liver metabolism. In this cross-sectional study, we analyzed the data from the 2017–2018 cycle of National Health and Nutrition Examination Survey to examine the associations between the proportion and composition of dietary fatty acid intakes with significant liver fibrosis among US population. The dietary fatty acid consumptions were calculated based on two 24-h dietary recalls. Significant liver fibrosis was diagnosed based on liver stiffness measurement value derived from the vibration controlled transient elastography. Multivariate logistic regression analysis and sensitivity analysis were performed to assess the association between dietary fatty acid consumption and significant liver fibrosis risk. Finally, restricted cubic spline analysis was carried out to explore the dose–response between polyunsaturated fatty acids (PUFA) or linoleic acid intakes and the risk of significant liver fibrosis. The results showed that the multivariate adjusted odds ratios (95% confidence intervals) of significant liver fibrosis were 0.34 (0.14–0.84), 0.68 (0.50–0.91), and 0.64 (0.47–0.87) for the highest level of unsaturated to saturated fatty acid ratio, dietary PUFA, and linoleic acid intakes compared to the lowest reference, respectively. The sensitivity analysis and restricted cubic spline analysis produced similar results, reinforcing the inverse association of unsaturated to saturated fatty acid ratio, PUFA, and linoleic acid consumptions with significant liver fibrosis risk. However, other dietary fatty acids did not show the statistically significant association with significant liver fibrosis. In conclusion, dietary linoleic acid may play a key role in the inverse association between the unsaturated to saturated fatty acid ratio and the risk of significant liver fibrosis. Further studies are needed to confirm these findings. |
| first_indexed | 2024-12-11T16:06:52Z |
| format | Article |
| id | doaj.art-c380d39e0fcf4934bb5eb116c0269553 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-11T16:06:52Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-c380d39e0fcf4934bb5eb116c02695532022-12-22T00:59:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-07-01910.3389/fnut.2022.938645938645Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide surveyTingting Zhu0Tingting Zhu1Tingting Zhu2Tingting Zhu3Xiao-Ting Lu4Xiao-Ting Lu5Zhao-Yan Liu6Zhao-Yan Liu7Hui-Lian Zhu8Hui-Lian Zhu9Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Food Science and Engineering, School of Food Science and Engineering, Hainan Tropical Ocean University, Sanya, ChinaCollaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing, Hainan Tropical Ocean University, Sanya, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaSince no pharmaceuticals have been proven to effectively reduce liver fibrosis, dietary fatty acids may be beneficial as one of the non-pharmaceutical interventions due to their important roles in liver metabolism. In this cross-sectional study, we analyzed the data from the 2017–2018 cycle of National Health and Nutrition Examination Survey to examine the associations between the proportion and composition of dietary fatty acid intakes with significant liver fibrosis among US population. The dietary fatty acid consumptions were calculated based on two 24-h dietary recalls. Significant liver fibrosis was diagnosed based on liver stiffness measurement value derived from the vibration controlled transient elastography. Multivariate logistic regression analysis and sensitivity analysis were performed to assess the association between dietary fatty acid consumption and significant liver fibrosis risk. Finally, restricted cubic spline analysis was carried out to explore the dose–response between polyunsaturated fatty acids (PUFA) or linoleic acid intakes and the risk of significant liver fibrosis. The results showed that the multivariate adjusted odds ratios (95% confidence intervals) of significant liver fibrosis were 0.34 (0.14–0.84), 0.68 (0.50–0.91), and 0.64 (0.47–0.87) for the highest level of unsaturated to saturated fatty acid ratio, dietary PUFA, and linoleic acid intakes compared to the lowest reference, respectively. The sensitivity analysis and restricted cubic spline analysis produced similar results, reinforcing the inverse association of unsaturated to saturated fatty acid ratio, PUFA, and linoleic acid consumptions with significant liver fibrosis risk. However, other dietary fatty acids did not show the statistically significant association with significant liver fibrosis. In conclusion, dietary linoleic acid may play a key role in the inverse association between the unsaturated to saturated fatty acid ratio and the risk of significant liver fibrosis. Further studies are needed to confirm these findings.https://www.frontiersin.org/articles/10.3389/fnut.2022.938645/fulldietary fatty acidsratio of unsaturated to saturated fatty acidsdietary fatty acid componentssignificant liver fibrosisnationwide study |
| spellingShingle | Tingting Zhu Tingting Zhu Tingting Zhu Tingting Zhu Xiao-Ting Lu Xiao-Ting Lu Zhao-Yan Liu Zhao-Yan Liu Hui-Lian Zhu Hui-Lian Zhu Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey Frontiers in Nutrition dietary fatty acids ratio of unsaturated to saturated fatty acids dietary fatty acid components significant liver fibrosis nationwide study |
| title | Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey |
| title_full | Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey |
| title_fullStr | Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey |
| title_full_unstemmed | Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey |
| title_short | Dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk: A nationwide survey |
| title_sort | dietary linoleic acid and the ratio of unsaturated to saturated fatty acids are inversely associated with significant liver fibrosis risk a nationwide survey |
| topic | dietary fatty acids ratio of unsaturated to saturated fatty acids dietary fatty acid components significant liver fibrosis nationwide study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.938645/full |
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