Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds
Cattle breeds used in industrial production tend to be larger than local cattle, as increased dairy and beef productivity is closely related to stature. This study aimed to identify single nucleotide polymorphisms (SNPs) significantly associated with stature in diverse cattle breeds. Thirteen local...
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MDPI AG
2022-08-01
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| author | Alexandra S. Abdelmanova Alexander A. Sermyagin Arsen V. Dotsev Nikolay V. Bardukov Margaret S. Fornara Gottfried Brem Natalia A. Zinovieva |
| author_facet | Alexandra S. Abdelmanova Alexander A. Sermyagin Arsen V. Dotsev Nikolay V. Bardukov Margaret S. Fornara Gottfried Brem Natalia A. Zinovieva |
| author_sort | Alexandra S. Abdelmanova |
| collection | DOAJ |
| description | Cattle breeds used in industrial production tend to be larger than local cattle, as increased dairy and beef productivity is closely related to stature. This study aimed to identify single nucleotide polymorphisms (SNPs) significantly associated with stature in diverse cattle breeds. Thirteen local and transboundary cattle breeds (<i>n</i> = 670) were divided into two groups according to their stature. The high-stature group included the Angus, Ayrshire, Black-and-White, Holstein, Kholmogor, Yaroslavl, Tagil, and Istoben breeds. The low-stature group included Jersey, Kalmyk, Kyrgyz, Mongolian, and Yakut. The average height at withers was 136.3 ± 1.6 and 121.6 ± 2.8 cm in the high- and low-stature groups, respectively. The samples of the 11 breeds were genotyped using high-density DNA arrays. Genotypes of the two remaining breeds were downloaded from the publicly available WIDDE database. Genome-wide association studies revealed seven SNPs strongly associated with stature, including three at 77.3–77.8 cM on BTA4 and four at 24.5–25.2 cM on BTA14. Functional annotation showed the localization within identified regions of genes responsible for growth, exterior characteristics, protein and lipid metabolism, and feed intake. The identified SNPs can be considered useful DNA markers for marker-assisted cattle breeding aimed at increasing stature. |
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| issn | 1424-2818 |
| language | English |
| last_indexed | 2024-03-09T04:33:18Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Diversity |
| spelling | doaj.art-c380d90a7d2d4ba288e652b72ec132022023-12-03T13:33:04ZengMDPI AGDiversity1424-28182022-08-0114869210.3390/d14080692Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle BreedsAlexandra S. Abdelmanova0Alexander A. Sermyagin1Arsen V. Dotsev2Nikolay V. Bardukov3Margaret S. Fornara4Gottfried Brem5Natalia A. Zinovieva6L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaL.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, Podolsk Municipal District, 142132 Podolsk, Moscow Region, RussiaCattle breeds used in industrial production tend to be larger than local cattle, as increased dairy and beef productivity is closely related to stature. This study aimed to identify single nucleotide polymorphisms (SNPs) significantly associated with stature in diverse cattle breeds. Thirteen local and transboundary cattle breeds (<i>n</i> = 670) were divided into two groups according to their stature. The high-stature group included the Angus, Ayrshire, Black-and-White, Holstein, Kholmogor, Yaroslavl, Tagil, and Istoben breeds. The low-stature group included Jersey, Kalmyk, Kyrgyz, Mongolian, and Yakut. The average height at withers was 136.3 ± 1.6 and 121.6 ± 2.8 cm in the high- and low-stature groups, respectively. The samples of the 11 breeds were genotyped using high-density DNA arrays. Genotypes of the two remaining breeds were downloaded from the publicly available WIDDE database. Genome-wide association studies revealed seven SNPs strongly associated with stature, including three at 77.3–77.8 cM on BTA4 and four at 24.5–25.2 cM on BTA14. Functional annotation showed the localization within identified regions of genes responsible for growth, exterior characteristics, protein and lipid metabolism, and feed intake. The identified SNPs can be considered useful DNA markers for marker-assisted cattle breeding aimed at increasing stature.https://www.mdpi.com/1424-2818/14/8/692local cattleGWASSNPQTLstatureallele frequency |
| spellingShingle | Alexandra S. Abdelmanova Alexander A. Sermyagin Arsen V. Dotsev Nikolay V. Bardukov Margaret S. Fornara Gottfried Brem Natalia A. Zinovieva Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds Diversity local cattle GWAS SNP QTL stature allele frequency |
| title | Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds |
| title_full | Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds |
| title_fullStr | Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds |
| title_full_unstemmed | Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds |
| title_short | Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds |
| title_sort | genome wide screening for snps associated with stature in diverse cattle breeds |
| topic | local cattle GWAS SNP QTL stature allele frequency |
| url | https://www.mdpi.com/1424-2818/14/8/692 |
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