Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice
Summary: Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to modulate noradrenergic responses, its s...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724000020 |
| _version_ | 1797291792342712320 |
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| author | Raniki Kumari Raluca Pascalau Hui Wang Sheetal Bajpayi Maria Yurgel Kwaku Quansah Samer Hattar Emmanouil Tampakakis Rejji Kuruvilla |
| author_facet | Raniki Kumari Raluca Pascalau Hui Wang Sheetal Bajpayi Maria Yurgel Kwaku Quansah Samer Hattar Emmanouil Tampakakis Rejji Kuruvilla |
| author_sort | Raniki Kumari |
| collection | DOAJ |
| description | Summary: Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to modulate noradrenergic responses, its specific roles in autonomic physiology remain under-appreciated. Here, we show that sympathetic-derived NPY is essential for metabolic and cardiovascular regulation in mice. NPY and NE are co-expressed in 90% of prevertebral sympathetic neurons and only 43% of paravertebral neurons. NPY-expressing neurons primarily innervate blood vessels in peripheral organs. Sympathetic-specific NPY deletion elicits pronounced metabolic and cardiovascular defects in mice, including reductions in insulin secretion, glucose tolerance, cold tolerance, and pupil size and elevated heart rate, while notably, however, basal blood pressure was unchanged. These findings provide insight into target tissue-specific functions of NPY derived from sympathetic neurons and imply its potential involvement in metabolic and cardiovascular diseases. |
| first_indexed | 2024-03-07T19:42:51Z |
| format | Article |
| id | doaj.art-c38856c2b284460a8201f052e4c441ab |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:51Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c38856c2b284460a8201f052e4c441ab2024-02-29T05:18:33ZengElsevierCell Reports2211-12472024-02-01432113674Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in miceRaniki Kumari0Raluca Pascalau1Hui Wang2Sheetal Bajpayi3Maria Yurgel4Kwaku Quansah5Samer Hattar6Emmanouil Tampakakis7Rejji Kuruvilla8Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USADepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USASection on Light and Circadian Rhythms, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USADivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USASection on Light and Circadian Rhythms, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USADepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USASection on Light and Circadian Rhythms, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USADivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USADepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA; Corresponding authorSummary: Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with norepinephrine (NE) in sympathetic neurons. Although NPY is generally considered to modulate noradrenergic responses, its specific roles in autonomic physiology remain under-appreciated. Here, we show that sympathetic-derived NPY is essential for metabolic and cardiovascular regulation in mice. NPY and NE are co-expressed in 90% of prevertebral sympathetic neurons and only 43% of paravertebral neurons. NPY-expressing neurons primarily innervate blood vessels in peripheral organs. Sympathetic-specific NPY deletion elicits pronounced metabolic and cardiovascular defects in mice, including reductions in insulin secretion, glucose tolerance, cold tolerance, and pupil size and elevated heart rate, while notably, however, basal blood pressure was unchanged. These findings provide insight into target tissue-specific functions of NPY derived from sympathetic neurons and imply its potential involvement in metabolic and cardiovascular diseases.http://www.sciencedirect.com/science/article/pii/S2211124724000020CP: NeuroscienceCP: Metabolism |
| spellingShingle | Raniki Kumari Raluca Pascalau Hui Wang Sheetal Bajpayi Maria Yurgel Kwaku Quansah Samer Hattar Emmanouil Tampakakis Rejji Kuruvilla Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice Cell Reports CP: Neuroscience CP: Metabolism |
| title | Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice |
| title_full | Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice |
| title_fullStr | Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice |
| title_full_unstemmed | Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice |
| title_short | Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice |
| title_sort | sympathetic npy controls glucose homeostasis cold tolerance and cardiovascular functions in mice |
| topic | CP: Neuroscience CP: Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724000020 |
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