Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy
Drug delivery systems are engineered platforms for the controlled release of various therapeutic agents. This paper presents a conductive gold leaf-based microfluidic platform fabricated using xurography technique for its potential implication in controlled drug delivery operations. To demonstrate t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/12/1169 |
| _version_ | 1797461170797412352 |
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| author | Ankita Sinha Adrian K. Stavrakis Mitar Simić Sanja Kojić Goran M. Stojanović |
| author_facet | Ankita Sinha Adrian K. Stavrakis Mitar Simić Sanja Kojić Goran M. Stojanović |
| author_sort | Ankita Sinha |
| collection | DOAJ |
| description | Drug delivery systems are engineered platforms for the controlled release of various therapeutic agents. This paper presents a conductive gold leaf-based microfluidic platform fabricated using xurography technique for its potential implication in controlled drug delivery operations. To demonstrate this, peppermint and eucalyptus essential oils (EOs) were selected as target fluids, which are best known for their medicinal properties in the field of dentistry. The work takes advantage of the high conductivity of the gold leaf, and thus, the response characteristics of the microfluidic chip are studied using electrochemical impedance spectroscopy (EIS) upon injecting EOs into its micro-channels. The effect of the exposure time of the chip to different concentrations (1% and 5%) of EOs was analyzed, and change in electrical resistance was measured at different time intervals of 0 h (the time of injection), 22 h, and 46 h. It was observed that our fabricated device demonstrated higher values of electrical resistance when exposed to EOs for longer times. Moreover, eucalyptus oil had stronger degradable effects on the chip, which resulted in higher electrical resistance than that of peppermint. 1% and 5% of Eucalyptus oil showed an electrical resistance of 1.79 kΩ and 1.45 kΩ at 10 kHz, while 1% and 5% of peppermint oil showed 1.26 kΩ and 1.07 kΩ of electrical resistance at 10 kHz respectively. The findings obtained in this paper are beneficial for designing suitable microfluidic devices to expand their applications for various biomedical purposes. |
| first_indexed | 2024-03-09T17:16:35Z |
| format | Article |
| id | doaj.art-c388c3ed0d2547f39b5f6035d09cb0fe |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T17:16:35Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-c388c3ed0d2547f39b5f6035d09cb0fe2023-11-24T13:37:47ZengMDPI AGBiosensors2079-63742022-12-011212116910.3390/bios12121169Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance SpectroscopyAnkita Sinha0Adrian K. Stavrakis1Mitar Simić2Sanja Kojić3Goran M. Stojanović4Faculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, 21000 Novi Sad, SerbiaFaculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, 21000 Novi Sad, SerbiaFaculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, 21000 Novi Sad, SerbiaFaculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, 21000 Novi Sad, SerbiaFaculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, 21000 Novi Sad, SerbiaDrug delivery systems are engineered platforms for the controlled release of various therapeutic agents. This paper presents a conductive gold leaf-based microfluidic platform fabricated using xurography technique for its potential implication in controlled drug delivery operations. To demonstrate this, peppermint and eucalyptus essential oils (EOs) were selected as target fluids, which are best known for their medicinal properties in the field of dentistry. The work takes advantage of the high conductivity of the gold leaf, and thus, the response characteristics of the microfluidic chip are studied using electrochemical impedance spectroscopy (EIS) upon injecting EOs into its micro-channels. The effect of the exposure time of the chip to different concentrations (1% and 5%) of EOs was analyzed, and change in electrical resistance was measured at different time intervals of 0 h (the time of injection), 22 h, and 46 h. It was observed that our fabricated device demonstrated higher values of electrical resistance when exposed to EOs for longer times. Moreover, eucalyptus oil had stronger degradable effects on the chip, which resulted in higher electrical resistance than that of peppermint. 1% and 5% of Eucalyptus oil showed an electrical resistance of 1.79 kΩ and 1.45 kΩ at 10 kHz, while 1% and 5% of peppermint oil showed 1.26 kΩ and 1.07 kΩ of electrical resistance at 10 kHz respectively. The findings obtained in this paper are beneficial for designing suitable microfluidic devices to expand their applications for various biomedical purposes.https://www.mdpi.com/2079-6374/12/12/1169pepperminteucalyptusessential oilselectrical resistancemicrofluidic chiporal dentistry |
| spellingShingle | Ankita Sinha Adrian K. Stavrakis Mitar Simić Sanja Kojić Goran M. Stojanović Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy Biosensors peppermint eucalyptus essential oils electrical resistance microfluidic chip oral dentistry |
| title | Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy |
| title_full | Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy |
| title_fullStr | Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy |
| title_full_unstemmed | Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy |
| title_short | Gold Leaf-Based Microfluidic Platform for Detection of Essential Oils Using Impedance Spectroscopy |
| title_sort | gold leaf based microfluidic platform for detection of essential oils using impedance spectroscopy |
| topic | peppermint eucalyptus essential oils electrical resistance microfluidic chip oral dentistry |
| url | https://www.mdpi.com/2079-6374/12/12/1169 |
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