Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase

Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase

Unstable DNA repeat expansions and insertions have been found to cause more than 50 neurodevelopmental, neurodegenerative, and neuromuscular disorders. One of the main hallmarks of repeat expansion diseases is the formation of abnormal RNA or protein aggregates in the neuronal cells of affected indi...

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Bibliographic Details
Main Authors: Ana S. Figueiredo, Joana R. Loureiro, Sandra Macedo-Ribeiro, Isabel Silveira
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
liquid/liquid phase separation
RNA-binding protein
RNA/protein aggregates
polyalanine
polyglutamine
NIID
Online Access:https://www.mdpi.com/2073-4409/12/6/826

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