Role of Retromer Complex in Neurodegenerative Diseases
Retromer is a protein complex that plays a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders. The process of intracellular trafficking and recycling is crucial for maintaining normal intracellular homeostasis, which is partl...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-03-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00042/full |
| _version_ | 1818193275096399872 |
|---|---|
| author | Li eChaosi Syed Zahid Ali Shah Zhao eDeming Lifeng eYang |
| author_facet | Li eChaosi Syed Zahid Ali Shah Zhao eDeming Lifeng eYang |
| author_sort | Li eChaosi |
| collection | DOAJ |
| description | Retromer is a protein complex that plays a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders. The process of intracellular trafficking and recycling is crucial for maintaining normal intracellular homeostasis, which is partly achieved through retromer complex. The retromer complex plays a primary role in sorting out the cargoes from endosomes back to the cell surface for reuse, to the trans-Golgi network (TGN) or alternatively to specialized endomembrane compartments away from lysosomal-mediated degradation. In most cases, the retromer acts as a core that interacts with associated proteins such as sorting nexin family member 27 (SNX27), the members of the vacuolar protein sorting 10 (VPS10) receptor family, the major endosomal actin polymerization-promoting complex known as wiskott-aldrich syndrome protein and scar homologue (WASH) or other proteins together in sorting the cargoes through various pathways, and some of these cargoes are risk factors for neurodegenerative diseases. Normally, there is a coordinated relationship between these pathways, however, when there is a defect such as haplo-insufficiency or mutation in itself or one or several units of retromer; it will lead to various pathologies.Here, we will summarize the molecular architecture of retromer complex and the roles of this system in intracellular trafficking signaling on pathogenesis of neurodegenerative diseases. |
| first_indexed | 2024-12-12T00:43:48Z |
| format | Article |
| id | doaj.art-c388fb17325c45a790bb2917e048b68a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T00:43:48Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-c388fb17325c45a790bb2917e048b68a2022-12-22T00:44:10ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-03-01810.3389/fnagi.2016.00042180688Role of Retromer Complex in Neurodegenerative DiseasesLi eChaosi0Syed Zahid Ali Shah1Zhao eDeming2Lifeng eYang3China Agricultural UniversityChina Agricultural UniversityChina Agricultural UniversityChina Agricultural UniversityRetromer is a protein complex that plays a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders. The process of intracellular trafficking and recycling is crucial for maintaining normal intracellular homeostasis, which is partly achieved through retromer complex. The retromer complex plays a primary role in sorting out the cargoes from endosomes back to the cell surface for reuse, to the trans-Golgi network (TGN) or alternatively to specialized endomembrane compartments away from lysosomal-mediated degradation. In most cases, the retromer acts as a core that interacts with associated proteins such as sorting nexin family member 27 (SNX27), the members of the vacuolar protein sorting 10 (VPS10) receptor family, the major endosomal actin polymerization-promoting complex known as wiskott-aldrich syndrome protein and scar homologue (WASH) or other proteins together in sorting the cargoes through various pathways, and some of these cargoes are risk factors for neurodegenerative diseases. Normally, there is a coordinated relationship between these pathways, however, when there is a defect such as haplo-insufficiency or mutation in itself or one or several units of retromer; it will lead to various pathologies.Here, we will summarize the molecular architecture of retromer complex and the roles of this system in intracellular trafficking signaling on pathogenesis of neurodegenerative diseases.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00042/fullParkinson's diseaseAlzheimer’s diseaseRetromer complexsorting nexin family member 27Wiskott-Aldrich syndrome protein and scar homologue |
| spellingShingle | Li eChaosi Syed Zahid Ali Shah Zhao eDeming Lifeng eYang Role of Retromer Complex in Neurodegenerative Diseases Frontiers in Aging Neuroscience Parkinson's disease Alzheimer’s disease Retromer complex sorting nexin family member 27 Wiskott-Aldrich syndrome protein and scar homologue |
| title | Role of Retromer Complex in Neurodegenerative Diseases |
| title_full | Role of Retromer Complex in Neurodegenerative Diseases |
| title_fullStr | Role of Retromer Complex in Neurodegenerative Diseases |
| title_full_unstemmed | Role of Retromer Complex in Neurodegenerative Diseases |
| title_short | Role of Retromer Complex in Neurodegenerative Diseases |
| title_sort | role of retromer complex in neurodegenerative diseases |
| topic | Parkinson's disease Alzheimer’s disease Retromer complex sorting nexin family member 27 Wiskott-Aldrich syndrome protein and scar homologue |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00042/full |
| work_keys_str_mv | AT liechaosi roleofretromercomplexinneurodegenerativediseases AT syedzahidalishah roleofretromercomplexinneurodegenerativediseases AT zhaoedeming roleofretromercomplexinneurodegenerativediseases AT lifengeyang roleofretromercomplexinneurodegenerativediseases |