Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives

Gastrointestinal (GI) cancers are major health burdens worldwide and biomarkers are needed to improve the management of these diseases along their evolution. Circulating tumor DNA (ctDNA) is a promising non-invasive blood and other bodily-fluid-based biomarker in cancer management that can help clin...

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Main Authors: Emilie Moati, Valerie Taly, Simon Garinet, Audrey Didelot, Julien Taieb, Pierre Laurent-Puig, Aziz Zaanan
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/19/4743
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author Emilie Moati
Valerie Taly
Simon Garinet
Audrey Didelot
Julien Taieb
Pierre Laurent-Puig
Aziz Zaanan
author_facet Emilie Moati
Valerie Taly
Simon Garinet
Audrey Didelot
Julien Taieb
Pierre Laurent-Puig
Aziz Zaanan
author_sort Emilie Moati
collection DOAJ
description Gastrointestinal (GI) cancers are major health burdens worldwide and biomarkers are needed to improve the management of these diseases along their evolution. Circulating tumor DNA (ctDNA) is a promising non-invasive blood and other bodily-fluid-based biomarker in cancer management that can help clinicians in various cases for the detection, diagnosis, prognosis, monitoring and personalization of treatment in digestive oncology. In addition to the well-studied prognostic role of ctDNA, the main real-world applications appear to be the assessment of minimal residual disease to further guide adjuvant therapy and predict relapse, but also the monitoring of clonal evolution to tailor treatments in metastatic setting. Other challenges such as predicting response to treatment including immune checkpoint inhibitors could also be among the potential applications of ctDNA. Although the level of advancement of ctDNA development in the different tumor localizations is still inhomogeneous, it might be now reliable enough to be soon used in clinical routine for colorectal cancers and shows promising results in other GI cancers.
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spelling doaj.art-c38a04d73d04423f9b666178885efc892023-11-22T15:51:41ZengMDPI AGCancers2072-66942021-09-011319474310.3390/cancers13194743Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and PerspectivesEmilie Moati0Valerie Taly1Simon Garinet2Audrey Didelot3Julien Taieb4Pierre Laurent-Puig5Aziz Zaanan6Department of Gastroenterology and Digestive Oncology, Institut du Cancer Paris Carpem, Assistance Publique des Hôpitaux de Paris, European Georges Pompidou Hospital, 75015 Paris, FranceCentre de Recherche des Cordeliers, INSERM UMRS1138, Centre National de la Recherche Scientifique, Sorbonne Université, USPC, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096, 75006 Paris, FranceCentre de Recherche des Cordeliers, INSERM UMRS1138, Centre National de la Recherche Scientifique, Sorbonne Université, USPC, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096, 75006 Paris, FranceCentre de Recherche des Cordeliers, INSERM UMRS1138, Centre National de la Recherche Scientifique, Sorbonne Université, USPC, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096, 75006 Paris, FranceDepartment of Gastroenterology and Digestive Oncology, Institut du Cancer Paris Carpem, Assistance Publique des Hôpitaux de Paris, European Georges Pompidou Hospital, 75015 Paris, FranceCentre de Recherche des Cordeliers, INSERM UMRS1138, Centre National de la Recherche Scientifique, Sorbonne Université, USPC, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096, 75006 Paris, FranceDepartment of Gastroenterology and Digestive Oncology, Institut du Cancer Paris Carpem, Assistance Publique des Hôpitaux de Paris, European Georges Pompidou Hospital, 75015 Paris, FranceGastrointestinal (GI) cancers are major health burdens worldwide and biomarkers are needed to improve the management of these diseases along their evolution. Circulating tumor DNA (ctDNA) is a promising non-invasive blood and other bodily-fluid-based biomarker in cancer management that can help clinicians in various cases for the detection, diagnosis, prognosis, monitoring and personalization of treatment in digestive oncology. In addition to the well-studied prognostic role of ctDNA, the main real-world applications appear to be the assessment of minimal residual disease to further guide adjuvant therapy and predict relapse, but also the monitoring of clonal evolution to tailor treatments in metastatic setting. Other challenges such as predicting response to treatment including immune checkpoint inhibitors could also be among the potential applications of ctDNA. Although the level of advancement of ctDNA development in the different tumor localizations is still inhomogeneous, it might be now reliable enough to be soon used in clinical routine for colorectal cancers and shows promising results in other GI cancers.https://www.mdpi.com/2072-6694/13/19/4743circulating tumor DNAgastrointestinal cancerspersonalized medicinebiomarker
spellingShingle Emilie Moati
Valerie Taly
Simon Garinet
Audrey Didelot
Julien Taieb
Pierre Laurent-Puig
Aziz Zaanan
Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
Cancers
circulating tumor DNA
gastrointestinal cancers
personalized medicine
biomarker
title Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
title_full Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
title_fullStr Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
title_full_unstemmed Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
title_short Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
title_sort role of circulating tumor dna in gastrointestinal cancers current knowledge and perspectives
topic circulating tumor DNA
gastrointestinal cancers
personalized medicine
biomarker
url https://www.mdpi.com/2072-6694/13/19/4743
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