Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link?
The expansion of the indication to use androgen deprivation therapy (ADT) to treat patients with advanced or metastatic prostate cancer has dramatically increased over the recent decades, resulting in the progress of patients’ survival. However, chronic health implications can become more apparent a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888221000192 |
| _version_ | 1797758458898939904 |
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| author | Myungsun Shim Woo Jin Bang Cheol Young Oh Yong Seong Lee Jin Seon Cho |
| author_facet | Myungsun Shim Woo Jin Bang Cheol Young Oh Yong Seong Lee Jin Seon Cho |
| author_sort | Myungsun Shim |
| collection | DOAJ |
| description | The expansion of the indication to use androgen deprivation therapy (ADT) to treat patients with advanced or metastatic prostate cancer has dramatically increased over the recent decades, resulting in the progress of patients’ survival. However, chronic health implications can become more apparent as the number of long-term cancer survivors is expected to be increased along with the adverse effect of ADT. In particular, interest in investigating ADT, especially luteinizing hormone-releasing hormone (LHRH) agonist association with cognitive dysfunction has been growing. Previous studies in animals and humans suggest that the level of androgen decreases with age and that cognitive decline occurs with decreases in androgen. Correspondingly, some of the extensive studies using common neurocognitive tests have shown that LHRH agonists may affect specific domains of cognitive function (e.g., visuospatial abilities and executive function). However, the results from these studies have not consistently demonstrated the association because of its intrinsic limitations. Large-scale studies based on electronic databases have also failed to show consistent results to make decisive conclusions because of its heterogeneity, complexity of covariates, and possible risk of biases. Thus, this review article summarizes key findings and discusses the results of several studies investigating the ADT association with cognitive dysfunction and risk of dementia from various perspectives. |
| first_indexed | 2024-03-12T18:30:16Z |
| format | Article |
| id | doaj.art-c38a75a1e89e4fd3bb8c914fa8932c8b |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T18:30:16Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-c38a75a1e89e4fd3bb8c914fa8932c8b2023-08-02T08:20:28ZengElsevierProstate International2287-88822022-03-011016874Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link?Myungsun Shim0Woo Jin Bang1Cheol Young Oh2Yong Seong Lee3Jin Seon Cho4Corresponding author. Department of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang, Gyeonggi-do, 14068, South Korea; Department of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, South KoreaDepartment of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, South KoreaDepartment of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, South KoreaDepartment of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, South KoreaDepartment of Urology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, South KoreaThe expansion of the indication to use androgen deprivation therapy (ADT) to treat patients with advanced or metastatic prostate cancer has dramatically increased over the recent decades, resulting in the progress of patients’ survival. However, chronic health implications can become more apparent as the number of long-term cancer survivors is expected to be increased along with the adverse effect of ADT. In particular, interest in investigating ADT, especially luteinizing hormone-releasing hormone (LHRH) agonist association with cognitive dysfunction has been growing. Previous studies in animals and humans suggest that the level of androgen decreases with age and that cognitive decline occurs with decreases in androgen. Correspondingly, some of the extensive studies using common neurocognitive tests have shown that LHRH agonists may affect specific domains of cognitive function (e.g., visuospatial abilities and executive function). However, the results from these studies have not consistently demonstrated the association because of its intrinsic limitations. Large-scale studies based on electronic databases have also failed to show consistent results to make decisive conclusions because of its heterogeneity, complexity of covariates, and possible risk of biases. Thus, this review article summarizes key findings and discusses the results of several studies investigating the ADT association with cognitive dysfunction and risk of dementia from various perspectives.http://www.sciencedirect.com/science/article/pii/S2287888221000192Adverse effectsAndrogen deprivationCognitive dysfunctionDementiaProstate cancer |
| spellingShingle | Myungsun Shim Woo Jin Bang Cheol Young Oh Yong Seong Lee Jin Seon Cho Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link? Prostate International Adverse effects Androgen deprivation Cognitive dysfunction Dementia Prostate cancer |
| title | Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link? |
| title_full | Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link? |
| title_fullStr | Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link? |
| title_full_unstemmed | Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link? |
| title_short | Androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer: is there a possible link? |
| title_sort | androgen deprivation therapy and risk of cognitive dysfunction in men with prostate cancer is there a possible link |
| topic | Adverse effects Androgen deprivation Cognitive dysfunction Dementia Prostate cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2287888221000192 |
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