Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals
OBJECTIVES: The study aimed to incorporate an estimate of risk for asbestos exposure in the Canadian Cancer Risk Management Lung Cancer (CRMM-LC) microsimulation model. METHODS: In CRMM-LC, a 3-year probability of developing lung cancer can be derived from different risk profiles. An asbestos-expose...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nordic Association of Occupational Safety and Health (NOROSH)
2015-07-01
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| Series: | Scandinavian Journal of Work, Environment & Health |
| Subjects: | |
| Online Access: |
https://www.sjweh.fi/show_abstract.php?abstract_id=3496
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| _version_ | 1818833107029065728 |
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| author | Natalie R Fitzgerald William M Flanagan William K Evans Anthony B Miller |
| author_facet | Natalie R Fitzgerald William M Flanagan William K Evans Anthony B Miller |
| author_sort | Natalie R Fitzgerald |
| collection | DOAJ |
| description | OBJECTIVES: The study aimed to incorporate an estimate of risk for asbestos exposure in the Canadian Cancer Risk Management Lung Cancer (CRMM-LC) microsimulation model. METHODS: In CRMM-LC, a 3-year probability of developing lung cancer can be derived from different risk profiles. An asbestos-exposed cohort was simulated and different scenarios of low-dose computerized tomography (LDCT) screening were simulated. RESULTS: As annual LDCT screening among non-asbestos-exposed individuals is less cost-effective than biennial screening, all the scenarios modeled for an asbestos-exposed cohort were biennial. For individuals with a two-fold risk of asbestos-induced lung cancer to be eligible for biennial LDCT screening, a smoking history of ≥15 pack-years would be necessary. For non-smokers with asbestos exposure resulting in a relative risk (RR) for lung cancer, it is not cost-effective to screen those with a RR of 5, but it is cost-effective to screen those with a RR of 10 (the heavily exposed). CONCLUSION: Asbestos-exposed individuals with an estimated two-fold or more risk of lung cancer from asbestos-exposure are eligible for LDCT screening at all ages from 55–74 years if they have a cigarette smoking history of ≥15 pack-years. Asbestos-exposed individuals who are lifelong non-smokers are eligible for LDCT screening at all ages from 55–74 years if they have accumulated a degree of asbestos exposure resulting in an estimated risk of lung cancer of ≥10. |
| first_indexed | 2024-12-19T02:13:39Z |
| format | Article |
| id | doaj.art-c38aeaa277be4530afdab3303bb80e8c |
| institution | Directory Open Access Journal |
| issn | 0355-3140 1795-990X |
| language | English |
| last_indexed | 2024-12-19T02:13:39Z |
| publishDate | 2015-07-01 |
| publisher | Nordic Association of Occupational Safety and Health (NOROSH) |
| record_format | Article |
| series | Scandinavian Journal of Work, Environment & Health |
| spelling | doaj.art-c38aeaa277be4530afdab3303bb80e8c2022-12-21T20:40:32ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2015-07-0141440741210.5271/sjweh.34963496Eligibility for low-dose computerized tomography screening among asbestos-exposed individualsNatalie R FitzgeraldWilliam M FlanaganWilliam K EvansAnthony B Miller0Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.OBJECTIVES: The study aimed to incorporate an estimate of risk for asbestos exposure in the Canadian Cancer Risk Management Lung Cancer (CRMM-LC) microsimulation model. METHODS: In CRMM-LC, a 3-year probability of developing lung cancer can be derived from different risk profiles. An asbestos-exposed cohort was simulated and different scenarios of low-dose computerized tomography (LDCT) screening were simulated. RESULTS: As annual LDCT screening among non-asbestos-exposed individuals is less cost-effective than biennial screening, all the scenarios modeled for an asbestos-exposed cohort were biennial. For individuals with a two-fold risk of asbestos-induced lung cancer to be eligible for biennial LDCT screening, a smoking history of ≥15 pack-years would be necessary. For non-smokers with asbestos exposure resulting in a relative risk (RR) for lung cancer, it is not cost-effective to screen those with a RR of 5, but it is cost-effective to screen those with a RR of 10 (the heavily exposed). CONCLUSION: Asbestos-exposed individuals with an estimated two-fold or more risk of lung cancer from asbestos-exposure are eligible for LDCT screening at all ages from 55–74 years if they have a cigarette smoking history of ≥15 pack-years. Asbestos-exposed individuals who are lifelong non-smokers are eligible for LDCT screening at all ages from 55–74 years if they have accumulated a degree of asbestos exposure resulting in an estimated risk of lung cancer of ≥10. https://www.sjweh.fi/show_abstract.php?abstract_id=3496 risk factorexposureasbestoscancersmokinglung cancerasbestos exposurecost-effectivenessmicrosimulationmathematical modelinglow-dose computerized tomographyct |
| spellingShingle | Natalie R Fitzgerald William M Flanagan William K Evans Anthony B Miller Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals Scandinavian Journal of Work, Environment & Health risk factor exposure asbestos cancer smoking lung cancer asbestos exposure cost-effectiveness microsimulation mathematical modeling low-dose computerized tomography ct |
| title | Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals |
| title_full | Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals |
| title_fullStr | Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals |
| title_full_unstemmed | Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals |
| title_short | Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals |
| title_sort | eligibility for low dose computerized tomography screening among asbestos exposed individuals |
| topic | risk factor exposure asbestos cancer smoking lung cancer asbestos exposure cost-effectiveness microsimulation mathematical modeling low-dose computerized tomography ct |
| url |
https://www.sjweh.fi/show_abstract.php?abstract_id=3496
|
| work_keys_str_mv | AT natalierfitzgerald eligibilityforlowdosecomputerizedtomographyscreeningamongasbestosexposedindividuals AT williammflanagan eligibilityforlowdosecomputerizedtomographyscreeningamongasbestosexposedindividuals AT williamkevans eligibilityforlowdosecomputerizedtomographyscreeningamongasbestosexposedindividuals AT anthonybmiller eligibilityforlowdosecomputerizedtomographyscreeningamongasbestosexposedindividuals |